FORMULATION AND EVALUATION OF ETODOLAC NIOSOMES BY MODIFIED ETHER INJECTION TECHNIQUE

Abstract

Etodolac is an indole acetic acid derivative with half-life of 4 to 7 hrs. It is used for the treatment of Rheumatoid arthritis. Whenever used orally, it has many systemic side effects, so it is not preferred orally. In present study four niosomes formulations of Etodolac were successfully developed by modified ether injection technique using different nonionic surfactant i.e. Span 20, Span 40, Tween 20, Tween 40 and cholesterol. Formulations were evaluated for different parameters like particle size, entrapment efficiency, in-vitro release, stability studies.


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Peer Review History:


Article received on-16 September, Revised 24 October,  Accepted 30 October, Available online 15 November 2016


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Received file


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Average Peer review marks at initial stage: 4.5/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Dr. Barkat Ali Khan


Affiliation: Kampala International University , Uganda


E-mail: barki.gold@gmail.com


Comments of reviewer(s):


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Keywords: Etodolac, niosomes, surfactants, cholesterol, modified ether injection method, in-vitro release, stability studies
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How to Cite
Chioma, E. “FORMULATION AND EVALUATION OF ETODOLAC NIOSOMES BY MODIFIED ETHER INJECTION TECHNIQUE”. Universal Journal of Pharmaceutical Research, Vol. 1, no. 1, Sept. 2016, doi:https://doi.org/10.22270/ujpr.v1i1.R1.
Section
Research Articles