FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE

  • Felix Sunday Yusuf Contec Global Agro Limited, Abuja, Nigeria.

Abstract

Objectives: Objective of present study involves preparation and evaluation of floating microballoons of Stavudine. It is a potent antiviral agent, used for treatment of human immunodeficiency virus (HIV) infection. In present study Stavudine is used as a model drug, to increase its residence time in the stomach without contact with the mucosa.


Methods: Eight floating microballoons formulations of Stavudine were prepared by using different polymers i.e. Eudragit S100, EC and PVP K30, in different ratio by emulsion solvent diffusion method. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of polymers (Eudragit S100, Ethyl cellulose and PVP K 30) as carriers.


Results: The mean particle diameter of the microballoons was between 230.23-238.33µm.The yield of microballoons was up to 68.32-80.22%. The cumulative percent drug release after 24 hrs of the Stavudine microballoons was in the range of 53.62 to 87.45%. The mean percentage buoyancy of the microballoons was between 69.23-82.53%. The cumulative percent drug release after 24 hrs of the Stavudine microballoons was 53.62 to 87.45%.


Conclusion: Stavudine floating microballoons formulations of batch MB4 was concluded as the optimum formulations among the all 8 formulations based on different parameters.Study concludes that stavudine can be delivered through floating microballoons dosage form in an effective way.


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Peer Review History:


Article received on- 29 September; Revised on- 20 October;    Accepted on- 5 November , Available online 15 November 2016


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Received file


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Average Peer review marks at initial stage: 4.5/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Dr. Michael Otakhor Erhunmwunse


Affiliation:  St. Philomena Catholic Hospital, Nigeria


E-mail: dedoctor4life@gmail.com


Comments of reviewer(s):


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FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE

Keywords: Stavudine, floating microballoons, floating drug delivery system, emulsion solvent diffusion method
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How to Cite
Yusuf, F. “FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE”. Universal Journal of Pharmaceutical Research, Vol. 1, no. 1, Sept. 2016, doi:https://doi.org/10.22270/ujpr.v1i1.R3.
Section
Research Articles