FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE
Objective of present study involves preparation and evaluation of floating microballoons of Stavudine. It is a potent antiviral agent, used for treatment of human immunodeficiency virus (HIV) infection. In present study Stavudine is used as a model drug, to increase its residence time in the stomach without contact with the mucosa. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of polymers (Eudragit S100, Ethyl cellulose and PVP K 30) as carriers. The yield of microballoons was up to 68.32-80.22 %.
The cumulative percent drug release after 24 hrs of the Stavudine microballoons was in the range of 53.62 to 87.45 %.
Peer Review History:
Article received on- 29 September; Revised on- 20 October; Accepted on- 5 November , Available online 15 November 2016
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Average Peer review marks at initial stage: 4.5/10
Average Peer review marks at publication stage: 7.5/10
Name: Dr. Michael Otakhor Erhunmwunse
Affiliation: St. Philomena Catholic Hospital, Nigeria
Comments of reviewer(s):