ROLE OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN ACUTE UPPER GASTROINTESTINAL BLEEDING

  • Soran Mohammed Gharib Ministry of Higher education and Scientific researched KRG, Ministry of Health KRG, Sulaimani City, Iraq- Kurdistan.

Abstract

Objectives: Many patients presented to the causality with upper gastrointestinal bleeding, which is a serious condition associated with significant morbidity and mortality especially in elderly patients and those with coexisting medical diseases. The purpose of the study was to assess the general use of NSAIDs and their relation to upper gastrointestinal bleeding.


Methods: Cross sectional study on patients who were referred for endoscopy for upper gastrointestinal bleeding in Sulaimany Teaching Hospital during the period from January to December 2016. All of them had been exposed to full history taking regarding age, gender, smoking, alcohol and medication used in addition to thorough physical examination and upper gastrointestinal endoscopic examination with biopsy when indicated.


Results: This study enrolled 100 patients with upper GIT bleeding and   showed that 48% of those with upper GIT bleeding were using NSAIDs, with male to female ratio of approximately 2:1, and 37 patients (77.1%) of those who were taken NSAIDs, did not use PPI concomitantly.


Conclusion:  The study also revealed that elderly patients taking NSAIDs were at higher risk of developing upper GIT bleeding.


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Peer Review History:


Article received on- 2 October; Revised on- 2 November; Accepted on- 4 November, Available online 15 November 2016


Academic Editor: 


Dr. A.A. Mgbahurikeorcid22.jpg, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com


UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.


Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 6.5/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Dr. Sally A. El-Zahabyorcid22.jpg, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com


Kian Navaeeorcid22.jpg, Shahre Daru Pharmaceutical Co., Iran, kian.navaee@chemist.com


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Keywords: NSAIDs, gastrointestinal bleeding

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How to Cite
Gharib, S. “ROLE OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN ACUTE UPPER GASTROINTESTINAL BLEEDING”. Universal Journal of Pharmaceutical Research, Vol. 1, no. 1, Sept. 2016, doi:https://doi.org/10.22270/ujpr.v1i1.R4.
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Research Articles