EpCAM- AN OLD CANCER ANTIGEN, TURNED ONCOGENIC RECEPTOR AND ITS TARGETING IMMUNOTHERAPY
EpCAM is a cell adhesion molecule. Its structure, its expression and the oncogenic potential, and its signaling network and target therapy were in concise reviewed. In recent advances, in addition to PI3K/akt and Raf/MAPK pathway involving in cell survival, anti-apoptosis and proliferation,and malignant initiation and progression, three distinct pathway are illustrated: EpCAM/E-cadherin-catenin-actin cytoskeleton, EpCAM/wint-catenin signaling and its major EpCAM/nuclear signaling presented by Maetzel D in 2009 and Munz M in 2004. Moreover, more accumulated data are needed in detail mechanism. The data may provide its cancer biology and clinical targeting therapy benefits.
Peer Review History:
Received 28 February 2018; Revised 25 April; Accepted 10 May, Available online 15 May 2018
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Average Peer review marks at initial stage: 4.5/10
Average Peer review marks at publication stage: 7.5/10
Name: Fatehalrahman F. Magbool
Affiliation: University of Khartoum, Sudan
Comments of reviewer(s):