FORMULATION AND EVALUATION OF IBUPROFEN GASTRO-RETENTIVE FLOATING TABLETS
Objective: The objective of the present study was to formulate the gastro-retentive floating tablets containing Ibuprofen, which would remain in stomach and/or upper part of GIT for prolonged period of time. Floating systems have low bulk density so that they can float on the gastric juice in the stomach. Ibuprofen is an anti inflammatory drug.
Methods: On trial and error basis formulation design was done. Four different batches of floating tablets of Ibuprofen were prepared using HPMC, Xanthan gum, and gas generating agent sodium bicarbonate and citric acid. The tablets were characterized for the pre and post compression parameters such as friability, hardness, thickness, drug content, weight variation, in-vitro buoyancy studies and 13 hrs in-vitro drug release studies and the results were within the limits.
Results: There was no interaction found in between drug and other ingredients. Maximum release was shown by formulation of batch F4 (47.38%), and minimum by the formulations of batch F2 (34.46%) in the duration of 13 hrs.
Conclusion: From the results obtained, it was concluded that the optimized formulation F4 desired drug release properties and floating behavior.
Peer Review History:
Received 13 June 2018; Revised 26 August; Accepted 3 September, Available online 15 September 2018
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Average Peer review marks at initial stage: 2/10
Average Peer review marks at publication stage: 7/10
Name: Dr. Heba M. Abd El-Azim
Affiliation: Damanhour University, Egypt
Name: Dr. Sally A. El-Zahaby
Affiliation: Pharos University in Alexandria, Egypt
Comments of reviewer(s):
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Sachin Sarashetti, Vikas Jain, Gowda D V, Pooja Mallya, & Satish Babu. (2020). Recent developments in orally disintegrating mini tablets. International Journal of Research in Pharmaceutical Sciences, 11(3), 3606-3612. Pubmed