ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS

  • Nahed Al-Baoqai Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, Sana'a University, Yemen.
  • Hassan Al-Mahbashi Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Sana`a University, Sanaa, Yemen. https://orcid.org/0000-0002-0149-3527
  • Adnan Al-Adhal Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, Sana'a University, Yemen

Abstract

Dracaena Cinnabari balf is a species plant in  Agavaceae family. It is a tree endemic to the Island of Socotra,Yemen. It was used as a dye and medicine in Socotra  and the Mediterranean basin. Some researches demonstrated both hypoglycemic and hypolipidemic of its resin of Dracaena Cochinchinensis, a traditional Chinese tree. Accordingly, this study aimed to evaluate the antidiabetic potential of the ethanolic extract of dracanea cinnabari balfresin (DCBR), endemic in Socotra Island, in Alloxan induced diabetes, and evaluation of possible antihyperlipidemic activity of the same extract in high-cholesterol diet-induced hyperlipidemia in male albino rats. Experimental diabetes was induced in rats with intraperitoneal injection a single dose of Alloxan (150 mg/kg). Hyperlipidemia was induced in rats by administration of 1% cholesterol in diet and 0.5 % Hydrogen Peroxide in drinking water for 14 days. Fasting blood glucose levels were measured at 1st day, 7th day and 14th day. Pancreas histopathology was done at the end. Estimation of serum lipid profile and liver   histopathology was done at the end of 14 day. The results were expressed as mean±SD and differences among the groups of animals were compared using one-way ANOVA. Administration of ethanolic extract of resin of two doses (100 and 300mg\kg) in alloxan induce diabetic rats resulted in a significant decrease in FBG levels with a recovery in destruction of pancreas cell compared with untreated group. Also the same doses of extract showed significant decrease in triglycerides, total cholesterol, low density lipoprotein, very low density lipoprotein and alkaline phospatase in comparing with untreated group. From the results of present study we can conclude the ethanolic extract of Dracaena Cinnabari Balf. have a hypoglycemic and hypolipidemic activity in experimental animals, these activity are time and dose dependent.  


Peer Review History:


Received 7 October 2018;   Revised 18 October; Accepted 1 November, Available online 15 November 2018


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Received file


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Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Name: Rana Ahmed Mohamed El-Saied El-Fitiany


Affiliation: Ahram Canadian University, Giza, Egypt


E-mail: marmarelfitiany@gmail.com


 


Name: Dr. Mohamed Derbali  


Affiliation: Faculty of Pharmacy, Monastir, Tunisia


E-mail: mohamed.edderbali@gmail.com


Comments of reviewer(s):


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Keywords: alloxan, blood glucose, diabetes, Dracanea Cinnabari, flavonoids, glibenclamide, resin
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How to Cite
Al-Baoqai, N., H. Al-Mahbashi, and A. Al-Adhal. “ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 5, Nov. 2018, doi:https://doi.org/10.22270/ujpr.v3i5.194.
Section
Research Articles