WOUND HEALING ACTIVITY OF JATROPHA TANJORENSIS LEAVES

  • Madepalli Byrappa gowdu Viswanathan Department of Plant Science, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India https://orcid.org/0000-0003-0120-1093
  • Jesu Doss Jeya Ananthi Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil – 626126, Tamil Nadu, India
  • NataRajan Livingston Raja Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil – 626126, Tamil Nadu, India
  • Narayanan Venkateshan Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil – 626126, Tamil Nadu, India https://orcid.org/0000-0002-7824-0798

Abstract

Objective:  The term “wound” is defined as a disruption of normal anatomical structure. Therefore, “healing” is the complex and dynamic process that results in the restoration of anatomical continuity and function.


Methods: Albino Wistar rats (150-180 g) of both sexes were selected. The experiment of Wound Healing Activity by Excision Wound Model and Incision Wound Model by the simple ointment B.P., reference standard drug (0.2% w/w nitrofurazone ointment), stigmasterol ointment (0.2% w/w), hexane, chloroform and methanol extract ointments of 3%, 4% and 5% w/w of leaves in Jatropha tanjorensis in simple ointment base (where 3g, 4g and 5 g of the extracts was incorporated in 100 g of simple ointment separately).


Results: The time for wound closure to methanol extract ointment (5% w/w) and stigmasterol (0.2% w/w) was similar to that of standard drug, nitrofurazone ointment (0.2% w/w) 16±2 days in Excision Wound Model. The significant tensile strength at 3%: 4%: 5% w/w methanol extract ointments (p<0.001), followed by chloroform extract and hexane extract. Stigmasterol ointment at 0.2% w/w produced tensile strength comparable with Standard drug, nitrofurazone ointment (0.2% w/w) (p<0.001) in Incision Wound Model.


Conclusion: Juice of the Jatropha plant and the pounded leaves are applied to wounds and refractory ulcers. The juice is very successfully used to treat scabies, eczema and ringworm. The present study proved that the leaves have wound healing activity.


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Peer Review History:


Received 5 September  2018;   Revised 28 September; Accepted 12 October, Available online 15 November 2018


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Received file


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Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Name:  Dr. Mohamed Said Fathy Al-Refaey


Affiliation: University of Sadat City, Menofia, Egypt


E-mail: mido_ph212@yahoo.com


 


Name: Prof. Dr. Hüsniye Kayalar


Affiliation: Ege University, Turkey


E-mail: husniyekayalar@gmail.com


Comments of reviewer(s):


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Keywords: excision, incision wound, Jatropha tanjorensis, leaves, wound healing
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How to Cite
Viswanathan, M. B. gowdu, J. D. Jeya Ananthi, N. Livingston Raja, and N. Venkateshan. “WOUND HEALING ACTIVITY OF JATROPHA TANJORENSIS LEAVES”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 5, Nov. 2018, doi:https://doi.org/10.22270/ujpr.v3i5.198.
Section
Research Articles