Objective:  Carbapenem resistance is a major and a future public health problem globally. It occurs mainly among Gram-negative bacteria.  Meropenem is the recently marketed carbapenem drug in Yemen. However, recent emergence of carbapenem-resistant isolates has become a major healthcare concern. The current study was designed to estimate the prevalence of meropenem resistance among hospitalised patients in Sana'a, Yemen.

Methods: The study was performed at a local hospital in Sana’a, Yemen. The records of Meropenem susceptibility were taken for hospitalised patients. A total of 443 Meropenem susceptibility samples were collected from August, 2017 to July, 2018. The meropenem susceptibility was studied against several isolated pathogens.

Results: Out of 443 study sample, 316 (71.3%) were meropenem sensitive isolates and 25.3% of samples were resistant. The Escherichia coli isolates were observed in 27.5% of sample, followed by Pseudomonas aeruginosa (19.6%). 36.4% of total meropenem sensitive isolates (115/316) were Escherichia coli. 82.4% (42/51) of Klebsiella pneumonia isolates were meropenem sensitive and 32.2% (28/87) of Pseudomonas aeruginosa were meropenem resistance. In the present study, 34.5% (109/316) of meropenem sensitive isolates were from blood cultures, followed by sputum cultures (23.7%; 75/316). However, 58% (65/112) of sputum culture isolates were meropenem resistance.

Conclusion: This study concluded that the percentage of resistance to meropenem was high (25.3%) and cannot be neglected. Continued surveillance to closely monitor trends as well as infection control and antibiotic stewardship activities are necessary to preserve treatment options. A more careful monitoring for use of broad-spectrum antibiotics should be instituted.


Peer Review History:

Received 6 November 2018;   Revised 11 November; Accepted 12 November, Available online 15 November 2018

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Received file


Average Peer review marks at initial stage: 4.5/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Name: Prof. Dr. Hüsniye Kayalar  

  Affiliation: Ege University, Turkey



Name: Noha El Baghdady 

Affiliation: MTI University, Cairo, Egypt


Comments of reviewer(s):


Keywords: Meropenem, prevalence, resistance
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How to Cite
Alyahawi, A., A. Alkaf, R. Alnamer, and T. Alnosary. “STUDY OF RESISTANCE FOR RECENTLY MARKETED CARBAPENEM DRUG AMONG HOSPITALISED PATIENTS IN SANA’A, YEMEN”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 5, Nov. 2018, doi:
Research Articles