STUDY OF RESISTANCE FOR RECENTLY MARKETED CARBAPENEM DRUG AMONG HOSPITALISED PATIENTS IN SANA'A, YEMEN
Objective: Carbapenem resistance is a major and a future public health problem globally. It occurs mainly among Gram-negative bacteria. Meropenem is the recently marketed carbapenem drug in Yemen. However, recent emergence of carbapenem-resistant isolates has become a major healthcare concern. The current study was designed to estimate the prevalence of meropenem resistance among hospitalised patients in Sana'a, Yemen.
Methods: The study was performed at a local hospital in Sana’a, Yemen. The records of Meropenem susceptibility were taken for hospitalised patients. A total of 443 Meropenem susceptibility samples were collected from August, 2017 to July, 2018. The meropenem susceptibility was studied against several isolated pathogens.
Results: Out of 443 study sample, 316 (71.3%) were meropenem sensitive isolates and 25.3% of samples were resistant. The Escherichia coli isolates were observed in 27.5% of sample, followed by Pseudomonas aeruginosa (19.6%). 36.4% of total meropenem sensitive isolates (115/316) were Escherichia coli. 82.4% (42/51) of Klebsiella pneumonia isolates were meropenem sensitive and 32.2% (28/87) of Pseudomonas aeruginosa were meropenem resistance. In the present study, 34.5% (109/316) of meropenem sensitive isolates were from blood cultures, followed by sputum cultures (23.7%; 75/316). However, 58% (65/112) of sputum culture isolates were meropenem resistance.
Conclusion: This study concluded that the percentage of resistance to meropenem was high (25.3%) and cannot be neglected. Continued surveillance to closely monitor trends as well as infection control and antibiotic stewardship activities are necessary to preserve treatment options. A more careful monitoring for use of broad-spectrum antibiotics should be instituted.
Peer Review History:
Received 6 November 2018; Revised 11 November; Accepted 12 November, Available online 15 November 2018
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Average Peer review marks at initial stage: 4.5/10
Average Peer review marks at publication stage: 7.0/10
Name: Prof. Dr. Hüsniye Kayalar
Affiliation: Ege University, Turkey
Name: Noha El Baghdady
Affiliation: MTI University, Cairo, Egypt
Comments of reviewer(s):