DEVELOPMENT AND CHARACTERIZATION OF DIRECT COMPRESSED MATRIX MINI TABLETS OF NAPROXEN SODIUM

  • Oyeniran Taiwo Opeyemi Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Nigeria.
  • Obanewa opeyemi Adegbenro Department of Physiology University of Ibadan, Nigeria

Abstract

Objective:  The present study was carried out to formulate and evaluate multiparticulate system containing mini-tablets of Naproxen sodium. Naproxen is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic properties.


Methods: Pre-formulation studies showed good flow and compaction capacity, leading to the production of high quality mini-tablets. The drug-excipients compatibility studies were performed using FTIR techniques. Ten different matrix mini tablets were manufactured by direct compression using various polymers like HPMC K4M, PVP K30 in different ratio. The prepared mini tablets were subjected to pre and post compressional parameters and the values were within the prescribed limits.


Results: The in-vitro performance showed the desired biphasic behaviour. Drug release from matrix mini tablets was sustained over a period of 10 hours and release rate.


Conclusion: Study concludes that Naproxen sodium can be successfully released in a controlled manner by the use of developed matrix mini-tablets.


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Peer Review History:


Received 4 October 2018;   Revised 20 October; Accepted 6 November, Available online 15 November 2018


Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeelorcid22.jpg, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com 


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Average Peer review marks at initial stage: 4.0/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Dr. Branislav Rankovićorcid22.jpg, University of Kragujevac, Serbia, rankovic@kg.ac.rs


Prof. Dr. Kapil Kumarorcid22.jpg, Global Institute of Pharmaceutical Education and Research,
Kashipur, US Nagar, Uttarakhand, India, kapil5november@gmail.com


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Keywords: HPMC K4M, in-vitro study, mini tablets, Naproxen sodium, NSAIDs, PVP K30

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How to Cite
Opeyemi, O. T., and O. opeyemi Adegbenro. “DEVELOPMENT AND CHARACTERIZATION OF DIRECT COMPRESSED MATRIX MINI TABLETS OF NAPROXEN SODIUM”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 5, Nov. 2018, doi:https://doi.org/10.22270/ujpr.v3i5.205.
Section
Research Articles