FORMULATION AND EVALUATION OF METOCLOPRAMIDE HCL RECTAL SUPPOSITORIES

  • Deborah Ejiogu Chioma Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria
  • Felix Sunday Yusuf Business Continuity Solutions, Neuts, Nigeria.
10.22270/ujpr.v3i6.218

Keywords:

Hydrogenated vegetable oil, in-vitro release study, Metoclopramide hydrochloride, suppositories

Abstract

Objective:  Metoclopramide hydrochloride is a dopamine receptor antagonist, used mostly for stomach and esophageal problems as it is a prokinetic agent. The aim of the present study was to design and evaluate the suppositories of Metoclopramide HCl. 

Methods: Six different, rectal suppositories were developed by fusion (pour-moulding) method by employing various hydrophilic and hydrophobic polymeric bases like gelatin, PEG-400 and hydrogenated vegetable oil using propylene glycol as plasticizer and beeswax as hardening agent.  Metoclopramide HCl suppositories were evaluated for appearance, weight variation, drug content uniformity, liquefaction time and temperature, micro-melting range, disintegration and in-vitro release study.  The in-vitro release rate data was evaluated statistically and was found that from all the formulations the drug release is by diffusion mechanism.

Results:  Optimum formulation of batch S1 has shown 83.427% Metoclopramide HCl in a study of 2 hrs. These drug release results are supported by the disintegration time of suppositories. Lesser the disintegration time faster the drug release. All formulations has shown zero, first and Higuchi release kinetics.

Conclusion: The result suggests that the Metoclopramide HCl suppositories can be prepared by employing hydrophilic and hydrophobic polymers.

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Peer Review History:

Received 28 October 2018;   Revised 19 November; Accepted 28 December, Available online 15 January 2019

Academic Editor: Dr. Nuray Arıorcid22.jpg, Ankara University, Turkiye, ari@ankara.edu.tr

Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif

Average Peer review marks at initial stage: 5.0/10

Average Peer review marks at publication stage: 8.0/10

Reviewer(s) detail:

Dr. Mahmoud S. Abdallahorcid22.jpg, University of Sadat city, Egypt, dr_samy777@yahoo.com

Dr. Sunita Singhorcid22.jpg, Baylor College of Medicine, Houston, Texas, USA, sunita.nccs@gmail.com

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Published

2019-01-11

How to Cite

Chioma, D. E., and F. S. Yusuf. “FORMULATION AND EVALUATION OF METOCLOPRAMIDE HCL RECTAL SUPPOSITORIES”. Universal Journal of Pharmaceutical Research, vol. 3, no. 6, Jan. 2019, doi:10.22270/ujpr.v3i6.218.

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Research Articles