ORAL DRUG DELIVERY OF INSULIN IN DIABETES MELLITUS: AN ATTRACTIVE ALTERNATE TO OVERCOME INVASIVE ROUTE
The subcutaneous injection of insulin for the treatment of diabetes mellitus can lead to patient non-compliance, discomfort, pain and local infection is a chronic metabolic health disease affecting the homeostasis of blood sugar levels in human beings. Oral route of drug delivery system has been the most widely accepted means of drug administration other than invasive drug delivery systems. For the development of an oral insulin delivery system, we have to focus on overcoming the various gastro-intestinal barriers for insulin uptake from the gastrointestinal tract. To overcome these barriers various types of formulations such as insulin conjugates, micro/nanoparticles, liposomes, hydrogel, capsule, and tablets are designed to deliver insulin orally. Various potential ways to administer insulin orally has been explored over years but a fluctuating level of insulin release have been recorded. A number of advancement has taken place in the recent years for understanding the needs of improved oral delivery systems of insulin. This review article concentrates on the challenges for oral drug delivery of insulin as well as various carriers used for the oral drug delivery of insulin and also provides the relevant information about the clinical tested formulations of oral insulin and its patents.
Peer Review History:
Received 16 December 2018; Revised 28 December; Accepted 31 December, Available online 15 January 2019
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Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 8.0/10
Name: Dr. Lucky Llegbosi Nwidu
Affiliation: University of Port Harcourt, Nigeria
Name: Prof. Dr. Syamsudin Abdillah
Affiliation: Pancasila University, Indonesia
Comments of reviewer(s):
Overall, this manuscript is good and very interesting to be discussed about nanovesicle including characterization, formulation, and stability test.