The subcutaneous injection of insulin for the treatment of diabetes mellitus can lead to patient non-compliance, discomfort, pain and local infection is a chronic metabolic health disease affecting the homeostasis of blood sugar levels in human beings. Oral route of drug delivery system has been the most widely accepted means of drug administration other than invasive drug delivery systems. For the development of an oral insulin delivery system, we have to focus on overcoming the various gastro-intestinal barriers for insulin uptake from the gastrointestinal tract. To overcome these barriers various types of formulations such as insulin conjugates, micro/nanoparticles, liposomes, hydrogel, capsule, and tablets are designed to deliver insulin orally. Various potential ways to administer insulin orally has been explored over years but a fluctuating level of insulin release have been recorded. A number of advancement has taken place in the recent years for understanding the needs of improved oral delivery systems of insulin. This review article concentrates on the challenges for oral drug delivery of insulin as well as various carriers used for the oral drug delivery of insulin and also provides the relevant information about the clinical tested formulations of oral insulin and its patents.


Peer Review History:

Received 16 December 2018;   Revised 28 December; Accepted 31 December, Available online 15 January 2019

UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.

Received file


Average Peer review marks at initial stage: 5.0/10

Average Peer review marks at publication stage: 8.0/10

Reviewer(s) detail:

Name: Dr. Lucky Llegbosi Nwidu

Affiliation: University of Port Harcourt, Nigeria

E-mail: menelucky@yahoo.com


Name: Prof. Dr. Syamsudin Abdillah

Affiliation: Pancasila University, Indonesia

E-mail: syamsudin.abdillah@gmail.com

Comments of reviewer(s):


Specific Comments:

Overall, this manuscript is good and very interesting to be discussed about nanovesicle including characterization, formulation, and stability test.

Keywords: Formulation technology, insulin, oral drug delivery, patient compliance
230 Views | 318 Downloads
How to Cite
Mathur, P., C. K. Mathur, and K. Mathur. “ORAL DRUG DELIVERY OF INSULIN IN DIABETES MELLITUS: AN ATTRACTIVE ALTERNATE TO OVERCOME INVASIVE ROUTE”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 6, Jan. 2019, doi:https://doi.org/10.22270/ujpr.v3i6.221.
Review Articles