FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE
Terbinafine is a broad spectrum antifungal drug. The aim of present study was to develop topical nano emulgel of terbinafine using carbopol 934 as a gelling agent. The objective behind the formulation was to avoid dosing frequency and to increase the stability and bioavailability by avoiding the first pass metabolism. The formulations were prepared by using oleic acid, carbopol 934, span 20, propylene glycol in different ratios and analyzed by pseudo tertiary phase diagram. All the five prepared nano emulgel formulations have shown satisfactory physiochemical properties. The stability and particle size is been determined by zeta potential. The highest drug release 82.38 %was found in formulations of batch F4, which follows non-fickian mechanism. The studies showed that changing the concentration of oil, surfactant, co surfactant and double distilled water as aqueous phase has an impact on the behavior and thermodynamic stability of the nanoemulsion. Study concludes that of Terbinafine can be deliverered effectively by nano emulgel formulations.
Peer Review History:
Received 28 November 2018; Revised 11 December; Accepted 25 December, Available online 15 January 2019
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Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 8.5/10
Name: Dr. Mohamed Salama
Affiliation: Modern University for Technology & Information, Egypt
Name: Dr. Mahmoud S. Abdallah
Affiliation: University of Sadat city, Egypt
Comments of reviewer(s):
Overall, this manuscript is good and very interesting to be discussed about nanovesicle including characterization, formulation, and stability test.