HEPATOPROTECTIVE ACTIVITY OF ASPARAGUS RACEMOSUS ROOT EXTRACT ON LIPOPOLYSACCHARIDE INDUCED OXIDATIVE STRESS IN RATS

  • Md. Parwez Ahmad Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal https://orcid.org/0000-0003-3755-2661
  • Tarannum Perween Department of Obstetrics and Gynaecology, Rahmania Medical Centre, Motihari, Bihar, India
  • Smita Singh Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
  • Ragni Sinha Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
  • Arshad Hussain Faculty of Pharmacy, King Khalid University, Kingdom of Saudi Arabia (KSA).
  • Shadma Wahab Faculty of Pharmacy, King Khalid University, Kingdom of Saudi Arabia (KSA).
  • Awadhesh Kumar Jha Department of Pharmacology, Government Medical College, Bettiah, India.

Abstract

Objective: Lipopolysaccharide (endotoxin) produces an inflammatory condition leading to multiple organ failure. LPS most potent bacterial products are used for induction of host oxidative stress responses and liver injury.


Methods: Present study was undertaken to investigate the effect of Asparagus racemosus Willd. root extract in lipopolysaccharide (LPS) induced oxidative stress in rats  by measuring oxidative stress markers, nitric oxide, liver function test and cytokines.


Results: The obtained data showed that LPS administration significantly reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), total cholesterol (TC) and albumin (ALB).   There was significant increase in malondialdehyde (MDA), cytokines activity, serum aspartate transaminase(AST), alanine transaminase(ALT), alkaline phosphate (ALP), total bilirubin (TB) and nitric oxide(NO).  


Conclusion: The methanolic extract of Asparagus   racemosus (MEAR) administration significantly (P<0.05) reduced LPS-induced oxidative stress by  normalizing liver GSH, SOD, CAT, MDA,  NO, cytokines and liver function markers. MEAR significantly increased ALB and TC level. Results suggest that MEAR protects the liver against liver toxicity induced by LPS.


Peer Review History:


Received 13 February 2019;   Revised 15 February; Accepted 5 March, Available online 15 March 2019


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Received file


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Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 8/10


Reviewer(s) detail:


Name: Dr. A.A. Mgbahurike


Affiliation: University of Port Harcourt, Nigeria


E-mail: amaka_mgbahurike@yahoo.com


Comments of reviewer(s):


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HEPATOPROTECTIVE ACTIVITY OF ASPARAGUS RACEMOSUS ROOT EXTRACT ON LIPOPOLYSACCHARIDE INDUCED OXIDATIVE STRESS IN RATS

Keywords: Asparagus racemosus, cytokine, hepatoprotective, lipopolysaccharide, oxidative stress, quercetin
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How to Cite
Ahmad, M. P., T. Perween, S. Singh, R. Sinha, A. Hussain, S. Wahab, and A. K. Jha. “HEPATOPROTECTIVE ACTIVITY OF ASPARAGUS RACEMOSUS ROOT EXTRACT ON LIPOPOLYSACCHARIDE INDUCED OXIDATIVE STRESS IN RATS”. Universal Journal of Pharmaceutical Research, Vol. 4, no. 1, Mar. 2019, doi:https://doi.org/10.22270/ujpr.v4i1.232.
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Research Articles