DEVELOPMENT AND EVALUATION OF NANOSPONGES LOADED EXTENDED RELEASE TABLETS OF LANSOPRAZOLE

Abstract

Nanosponges are tiny sponges with an average diameter below 1µm and consist of cavities filled with drug molecules. Lansoprazole is one of the classes of proton pump inhibitors, it reduces gastric acidity, and used in disorders such as gastric ulcer, duodenal ulcer and reflux oesophagitis.   In present study for extended delivery of lansoprazole at optimal concentration and to reduce the frequency of dosing and thus to increase patient convenience nanosponges loaded extended release tablets were prepared. Initially four different nanosponges formulations were prepared by solvent evaporation method and evaluated on various parameters. Ethyl cellulose was used as entrapping agent and dichloromethane as cross linking agent in various proportions and evaluated for powder flow properties, % yield, zeta potential, and in-vitro drug release characteristics. Based on the evaluation results, formulation NS1 was selected to prepare five extended release tablets formulations by using HPMC K30 and chitosan as extended release polymers. All five formulations were evaluated for thickness, hardness, friability, % drug content and in-vitro drug release. From the results, it was found that all the evaluation results are within pharmacopoeial limits. From this study, we concluded feasibility of extended release of Lansoprazole through nanosponge loaded extended release tablets. Formulation of batch NT1, containing HPMC K30 was found to be optimum formulation.


Peer Review History:


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Received file


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Average Peer review marks at initial stage: 3/10


Average Peer review marks at publication stage:7.5/10


Reviewer(s) detail:


Name: Dr. A.A. Mgbahurike


Affiliation: University of Port Harcourt, Nigeria


E-mail: amaka_mgbahurike@yahoo.com


Comments of reviewer(s):


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Keywords: Entrapment efficiency, ethyl cellulose, HPMC, in-vitro drug release, lansoprazole,, nanosponges
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How to Cite
Francis, D. J. E., and F. S. Yusuf. “DEVELOPMENT AND EVALUATION OF NANOSPONGES LOADED EXTENDED RELEASE TABLETS OF LANSOPRAZOLE”. Universal Journal of Pharmaceutical Research, Vol. 4, no. 1, Mar. 2019, doi:https://doi.org/10.22270/ujpr.v4i1.239.
Section
Research Articles