FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS
The aim of the present investigation was to develop oral controlled release matrix tablet formulations of Finasteride with different polymer ratios. Finasteride is chemically considered a synthetic 4-azasteroid drug. The granules were evaluated for angle of repose, bulk density and Compressibility index before being punched as tablets. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and/or standard references. Different models for kinetic study were applied like zero order, first order, Higuchi, Hixson Crowell and Korsmeyer to study the release pattern and mechanism.
Peer Review History:
Article received on- 16 November, Revised on- 25 December, Accepted on- 28 December, Available online 15 January 2017
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Average Peer review marks at initial stage: 4.0/10
Average Peer review marks at publication stage: 7.0/10
Name: Dr. Barkat Ali Khan
Affiliation: Kampala International University, Uganda
Comments of reviewer(s):