FORMULATION AND EVALUATION OF ETORICOXIB MICROBEADS FOR SUSTAINED DRUG DELIVERY
The aim of the study was to develop novel drug design of etoricoxib microbeads for sustained drug delivery by oral route which reduces the dosing frequency. Etoricoxib is a NSAIDs commonly used by patients so to reduce the dosing frequency of drug administration the etoricoxib loaded microbeads were prepared with sodium alginate and calcium chloride in different ratios by inotropic gelation technique and characterized by FTIR, drug entrapment efficiency, particle size, swelling Index and release profile. The microbeads show that 3.86±0.28% of surface entrapment, drug content87±0.35%, swelling Index was found to be 80.76 and 88.72±0.15drug entrapment of F4 formulation depending on polymer/drug ratio. The IR spectrum shows stable character of etoricoxib in the microbeads and revealed an absence of drug polymer interaction. The prepared microbeads were spherical in shape and had a size range of 125±0.02to 165±0.18µm, the release of the drug was found to be 64.092±0.24 in F4 formulation among all formulation in 240 minutes which shows that the drug released by sustained effect and shows kinetic release mechanism the formulation F1 shows fickian diffusion and F2, F3 and F4 shows the super-case Ⅱ transport which depends upon the loss of polymeric chain and the release of drug takes place.
Peer Review History:
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Average Peer review marks at initial stage: 3.5/10
Average Peer review marks at publication stage: 7/10
Name: Dr. A.A. Mgbahurike
Affiliation: University of Port Harcourt, Nigeria
Comments of reviewer(s):