FORMULATION AND EVALUATION OF ETORICOXIB MICROBEADS FOR SUSTAINED DRUG DELIVERY
Objective: The aim of the study was to develop novel drug design of etoricoxib microbeads for sustained drug delivery by oral route which reduces the dosing frequency. Etoricoxib is a NSAIDs commonly used by patients so to reduce the dosing frequency of drug administration the etoricoxib loaded microbeads were prepared.
Methods: Formulations were prepared with sodium alginate and calcium chloride in different ratios by inotropic gelation technique and characterized by FTIR, drug entrapment efficiency, particle size, swelling Index and release profile.
Results: The microbeads show that 3.86±0.28% of surface entrapment, drug content 87±0.35%, swelling Index was found to be 80.76. The IR spectrum shows stable character of etoricoxib in the microbeads and revealed an absence of drug polymer interaction. The prepared microbeads were spherical in shape and had a size range of 125±0.02to 165±0.18µm, the release of the drug was found to be 64.092±0.24 in F4 formulation among all formulation in 240 minutes which shows that the drug released by sustained effect and shows kinetic release mechanism the formulation F1 shows fickian diffusion and F2, F3 and F4 shows the super-case, transport which depends upon the loss of polymeric chain and the release of drug takes place.
Conclusion: The formulation F4 was found to be the best among all the other formulation because the percentage yield was found to be 80.6% among all formulation.
Peer Review History:
Received 1 January 2019; Revised 8 February; Accepted 2 March, Available online 15 March 2019
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Average Peer review marks at initial stage: 3.5/10
Average Peer review marks at publication stage: 7/10