ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA

Abstract

Objectives:  Baphia nitida is a tropical plant used in African folkloric medicine for the treatment of infections and inflammatory conditions. This study therefore seeks to investigate the biological activities including antioxidant and anti-inflammatory properties of leaf and root methanol extracts of B. nitida.


Methods: Anti-inflammatory activity of extract was investigated by the carrageenan-induced paw edema model of inflammation, respectively. The antioxidant properties of the extracts as determined by the DPPH free radical scavenging assay.


Results: The result showed that B. nitida extract caused a concentration dependent percentage increase of antioxidant activity. The leaves and root extract demonstrated potent anti-inflammatory activity at low concentrations of between 25-75 mg /kg body weight. The ascorbic acid standard had a better antioxidant activity of 63.59% at the concentration of 10 µg/ml and 81.63%  at  400 µg/ml.


Conclusion: The methanol root extract at lower doses exhibited anti-inflammatory properties. Methanol leaf extract than the root extract. Both the leaf and root extracts of B. nitida exhibited antioxidant activity.


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Peer Review History:


Article received on- 23 November,       Revised on- 28 November,       Accepted on- 30 December, Available online 15 January 2017


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Received file


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Average Peer review marks at initial stage: 4.0/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Name: Dr. Xinwei Li


Affiliation: Jilin University, China


E-mail: lixinwei100@jlu.edu.cn


Comments of reviewer(s):


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Keywords: Baphia nitida, anti-oxidant, anti-inflammatory, carrageenan-induced paw edema
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How to Cite
Chioma, D. “ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA”. Universal Journal of Pharmaceutical Research, Vol. 1, no. 2, Nov. 2016, doi:https://doi.org/10.22270/ujpr.v1i2.R5.
Section
Research Articles