• Dingwoke Francis John Department of biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria
  • Unus A A Department of biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria
  • Udokwu Japheth Chigbo Department of biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria
  • Ugwoke Sunday Paul Department of Pharmacy, University of Notingham, NG72RD, United Kingdom.
  • Ezeaku Ikenna Department of Pharmacy, Kaplan School of Medicine, Chicago, Illinois, USA.


Objectives: Liposomes are colloidal particles formed as concentric bimolecular layers that are capable of encapsulating drugs. Liposomes have the potential for extending the duration of action for days or months. Tolnaftate is used as the topical antifungal agent.  The purpose of this study was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability. 

Methods: In present study, four different liposomes formulations of Tolnaftate were prepared by ethanol (solvent) injection method by varying the concentrations of phospholipids. The prepared liposomes were characterized for size, shape, entrapment efficiency, zeta potential, in-vitro drug release.

Results: The % entrapment efficiency was found to be in the range of 90.24, 90.75, and 90.75%. The % entrapment efficiency of optimized batch LS4 was found to be 90.74 %. An in vitro drug release of about 82.114 % in 10 h was observed from optimum formulation of batch LS4.

Conclusion: Based on different parameters like particle size, entrapment efficiency, drug release formulations of batch LS4 was selected as best formulation. Study concludes that Tolnaftate liposomes have potential for providing sustained delivery of drug.


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Peer Review History:

Article received on- 15 November 2016,       Revised on- 20 December,           Accepted on- 3 January, Available online 15 January 2017

Academic Editor: Dr. Amany Mohamed Alboghdadlyorcid22.jpg, Princess Nourah bint abdulrahman university, Riyadh,

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Average Peer review marks at initial stage: 4.0/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Dr. Mahmut Yıldıztekinorcid22.jpg, Muğla Sıtkı Koçman University, Turkey,

Dr. Mohamed Derbaliorcid22.jpg, Faculty of Pharmacy, Monastir, Tunisia,

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Keywords: Tolnaftate, liposomes, phospholipid, entrapment efficiency, zeta potential, in-vitro drug release


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How to Cite
John, D., U. A, U. Chigbo, U. Paul, and E. Ikenna. “TOLNAFTATE LOADED LIPOSOMES- DESIGN, AND IN-VITRO EVALUATION”. Universal Journal of Pharmaceutical Research, Vol. 1, no. 2, Nov. 2016, doi:
Research Articles