_1568706773
1568706773
Editor
editor.jddt@gmail.com
UJPR
Universal Journal of Pharmaceutical Research
Univ J Pharm Res
2456-8058
09
15
2019
FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS CONTAINING EXTRACT OF SOLENOSTEMMA ARGEL (HARGEL)
Abdullah Hameed
Maad
Mohammed El-Hassan
Ali Shayoub
Elamin Ibrahim
Elnima
Zuheir
Osman
Fatehalrahman
F. Magbool
The objective of the present study is to formulate colon targeted matrix tablets containing Solenostemma argel extract using guar gum alone or in combination with either HPMC K15M, with Eudragit S100, or with both them. The Hargel colon targeted matrix tablets were prepared by wet granulation method. The prepared matrix tablets were evaluated for the weight variation, hardness, friability, and in-vitro drug release study in three different media. The formulations showed compliance with pharmacopial standards except that containing guar gum alone. There was no interaction between drug, polymer and other excipients. It was confirmed by FTIR studies. Among the formulations, GHE2 (i.e. containing triple polymer mixture) showed good results in release retardation and other physicochemical properties of matrix tablets when compare to other formulations. The optimum formulation (GHE2) was stable when it was stored at 450/75% RH for 3 months. The formulation GHE2 was considered the most suitable formula for targeted the colon.
09
12
2019
10.22270/ujpr.v4i4.297
http://ujpr.org/index.php/journal/article/view/297
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http://ujpr.org/index.php/journal/article/download/297/368
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http://ujpr.org/index.php/journal/article/download/297/380
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http://ujpr.org/index.php/journal/article/download/297/368
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http://ujpr.org/index.php/journal/article/download/297/380