MOST IMPORTANT CELLULAR CHANGES INVOLVED IN RENAL ISCHEMIA REPERFUSION INJURY AND THE CONSEQUENT IMPACT ON SELECTED REMOTE ORGANS

  • Asmaa A. Khalifa Department of Pharmacology and therapeutics , Faculty of Pharmacy, Pharos University, Alexandria, Egypt
  • Mai El-Sayed Ghoneim Department of pharmacology and toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.

Abstract

Because of the high rate of baseline oxygen use by renal cells, kidney is highly influenced by obstruction of arterial blood inflow and subsequent shortage of the received oxygen, this condition is known as Ischemic injury. There are many clinical settings associated with unavoidable ischemic state such as kidney transplantation, partial nephrectomy or suprarenal procedures of the aorta. During ischemia many cellular changes occur including vascular congestion and adhesion of inflammatory cells to the endothelium with subsequent infiltration into the kidney tissue. Following ischemia, a phase known as Reperfusion begins and
involves a return of blood and oxygen supply to micro vessels. Reperfusion was expected to restore the damage occurred during the ischemic phase, paradoxically, reperfusion leads to more congestion, red cells trapping and excessive generation of reactive oxygen species (ROS), which can oxidatively modify significantly every type of biomolecule, thereby inducing cell dysfunction and induce reperfusion injury. Ischemia reperfusion injury (IRI) is also related to a phenomenon called Remote Organ Injury (ROI) in which the damaging effect induced by I/R is not only restricted to the tissue that undergoing the initial ischemia but also
it leads to injury to remote organs such as the liver, lung, gut. ROI usually occurs by the same mechanisms seen in the local injury induced by I/R including the generation of ROS, leukocytes, and inflammatory mediators (e.g; TNF-α). These substances are directly released from the primary injured tissue or indirectly from activated leukocytes or other inflammatory cells causing organ dysfunctions in distant organs.


141.JPG


Google_scholar_image5.JPG       PubMed9.jpg


Peer Review History:


Received 3 March 2018;   Revised 8 March; Accepted 11 March, Available online 15 March 2018


UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.


Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 8.5/10


Reviewer(s) detail:


Dr. Francis Adou Yapoorcid22.jpg, Felix Houphouet Boigny, University of Abidjan, Ivory Coast, fyapo@yahoo.fr


Dr. Fátima Morales Marínorcid22.jpg, University of Murcia, Spain, fatima.morales@um.es


This article has been cited by:


Dalia Ibrahim Ismail email orcid ; Alshaymaa Gamal Aboulkhair. The Effect of Aliskiren on Renal Cortical Ischemia/Reperfusion Injury in Albino Rats: A Histological and Immunohistochemical Study. Article 6, Volume 42, Issue 4, Autumn 2020, Page 838-848. Pubmed

Keywords: remote organ injury, Renal ischemia, reperfusion injury reactive oxygen species (ROS), inflammatory response

Downloads

Download data is not yet available.
Comments

Statistics
360 Views | 453 Downloads
How to Cite
Khalifa, A., and M. Ghoneim. “MOST IMPORTANT CELLULAR CHANGES INVOLVED IN RENAL ISCHEMIA REPERFUSION INJURY AND THE CONSEQUENT IMPACT ON SELECTED REMOTE ORGANS”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 1, Mar. 2018, doi:https://doi.org/10.22270/ujpr.v3i1.RW1.
Section
Review Articles