The objective of the present study was to formulate solid dispersions (SD) of Ezetimibe to improve the solubility and dissolution rate to facilitate faster onset of action. Ezetimibe is a poorly water soluble BCS class II drug and used as a hypolipidemic agent. It has poor bioavailability (35-65%) due to its low dissolution profile in gastro intestinal tract. In the present study, eight solid dispersion formulations of Ezetimibe with polymers PEG-4000 and PEG-6000 were prepared by solvent evaporation and fusion methods.  Solid dispersion formulations were characterized by content uniformity, flow properties and in vitro dissolution studies. Present study concluded that the Ezetimibe solid dispersion formulations are a suitable approach to improve the solubility and dissolution rate of ezetimibe than pure form of drug.


Peer Review History:

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Received file


Average Peer review marks at initial stage: 4.0/10

Average Peer review marks at publication stage: 8.0/10

Reviewer(s) detail:

Name: Dr  Murtaza M. Tambuwala                                     

Affiliation: Ulster University, Ireland

E-mail: m.tambuwala@ulster.ac.uk

Comments of reviewer(s):


Keywords: Ezetimibe, PEG-4000, PEG-6000, solid dispersion
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How to Cite
Jajere, U., and A. E. “FABRICATION AND CHARACTERIZATION OF EZETIMIBE SOLID DISPERSION FOR SOLUBILITY ENHANCEMENT”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 1, Jan. 2017, doi:https://doi.org/10.22270/ujpr.v2i1.R3.
Research Articles