DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM

Abstract

The objective of the present study was to formulate solid dispersions (SD) of Ezetimibe to Transdermal drug delivery systems deliver the drug through the skin at controlled rate to the systemic circulation. It maintains the blood concentration of the drug within the therapeutic system window ensuring that drug levels neither fall below the minimum effective concentration nor exceed the minimum toxic dose. The objective of the present work was to formulate transdermal gel of Lornoxicam. It is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis. Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, HPMC K100 and EC as polymers. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability.  Invitro release study was performed for 10 hrs.  Selected formulation was subjected to stability testing at different temperatures.


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Peer Review History:


Received 7 February 2017;   Revised 11 March; Accepted 13 March, Available online 15 March 2017


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Received file


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Average Peer review marks at initial stage: 4.0/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Prof. Dr. Syamsudin Abdillah     


Affiliation: Pancasila University, Indonesia


E-mail: syamsudin.abdillah@gmail.com


Comments of reviewer(s):


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Keywords: Lornoxicam, transdermal gel, pH, viscosity, spreadability in-vitro release, stability studies
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How to Cite
Umar, S., and M. Onyekachi. “DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 1, Jan. 2016, doi:https://doi.org/10.22270/ujpr.v2i1.R4.
Section
Research Articles