PHYTOCHEMICAL INVESTIGATION AND EVALUATION OF ANTIOXIDANT AND THROMBOLYTIC PROPERTIES OF LEAVE EXTRACTS OF GARDENIA CORONARIA BUCH-HAM

  • Md. Mominur Rahman Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh https://orcid.org/0000-0003-2357-283X
  • Md. A.K. Azad Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh https://orcid.org/0000-0002-9788-5217
  • Tanjin Ahmed Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh
  • Nusrat Rahman Nizhum Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh https://orcid.org/0000-0002-3153-5679
  • Fahadul Islam Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh
  • Nusrat Jahan Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh https://orcid.org/0000-0001-6229-1200
  • Moriam Akter Sumi Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh https://orcid.org/0000-0001-7126-4888
  • Khandaker Sanjida Akter Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh https://orcid.org/0000-0001-7660-4888
  • Md. Faysal Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh https://orcid.org/0000-0001-5948-4749
  • M Mukhles Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka-1207, Bangladesh

Abstract

Objective: The objective of this study was assessing the diverse pharmacological efficacies of methanolic extracts of the whole plant of Gardenia coronaria Buch-Ham This study illustrates the phytochemicals, antioxidants and thrombolytic activity which have the possibility to be used in the coming future to open a new line of investigation. The Gardenia coronaria, one of the necessary traditional medicinal plants in Bangladesh. In the rural area this plant is used by a lot of people as a treatment from various disease.


Methods: Total sum of the flavonoids was spectrophotometrically ascertained with the help of aluminum chloride colorimetric assay as total phenolic and tannin content by Folin Chiocalteu’s reagent. Antioxidant activity, ascertained by DPPH (α, α-diphenyl-β-picrylhydrazyl) free radical scavenging assay giving some comparison between the resultant activity with the standard. The thombolytic activity was assessed based on the method of minor alterations.


Results: The percentage of clot lysis was 87.58% when 100 μl of streptokinase (30,000 I.U.), and the methanolic extract displayed the least clot lysis activity (26.79%), much less compared to the standard. It can be elicited that the extract of Gardenia coronaria Buch-Ham contains antioxidant and thrombolytic activity. The potential of these activities probably because of the availability of most of the phytochemicals supporting previous claims and verify its uses as an expected folk medicine. 


Peer Review History:


Received 9 January 2020;   Revised 25 January; Accepted 4 March, Available online 15 March 20200


UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.


Received file


pdf3.JPG


Average Peer review marks at initial stage: 4.5/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Name: Dr. Gehan Fawzy Abdel Raoof Kandeel


Affiliation: Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt


E-mail: gehankandeel9@yahoo.com


 


Name: Dr. Marwa A. A. Fayed  


Affiliation: University of Sadat City, Egypt


E-mail: maafayed@gmail.com


Comments of reviewer(s):


word_icon_3.jpg


Similar Articles:


COMPARATIVE ANALYSIS OF THE PHYTOCHEMICAL COMPOSITIONS OF LEAF, STEM-BARK AND ROOT OF AZADIRACHTA INDICA (NEEM)


EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA

Keywords: Antioxidant, Gardenia coronaria, flavonoid, thrombolytic, traditional medicine
Statistics
34 Views | 14 Downloads
How to Cite
Rahman, M. M., M. A. Azad, T. Ahmed, N. R. Nizhum, F. Islam, N. Jahan, M. A. Sumi, K. S. Akter, M. Faysal, and M. Mukhles. “PHYTOCHEMICAL INVESTIGATION AND EVALUATION OF ANTIOXIDANT AND THROMBOLYTIC PROPERTIES OF LEAVE EXTRACTS OF GARDENIA CORONARIA BUCH-HAM”. Universal Journal of Pharmaceutical Research, Vol. 5, no. 1, Mar. 2020, doi:https://doi.org/10.22270/ujpr.v5i1.356.
Section
Research Articles