ANTIFUNGAL EFFECTS OF TAPINANTHUS GLOBIFERUS GROWING ON VITEXDONIANA AGAINST SOME FUNGAL ISOLATES

  • H Abubakar Department of Chemistry, Sokoto State University, Sokoto, Nigeria.
  • AM Musa Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University Zaria, Nigeria.
  • MI Abdullahi Department of Pharmaceutical and Medicinal Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria. https://orcid.org/0000-0002-9049-9057
  • AJ Yusuf Department of Pharmaceutical and Medicinal Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria. https://orcid.org/0000-0002-4557-859X

Abstract

Objective: Fungal infections are the major cause of many skin diseases, especially in developing countries. Natural products of medicinal value represent a potential source of chemotherapeutic agents. Tapinanthus globiferus has been used extensively in ethnomedicine for the treatment hypertension, ulcer, cancer, diabetes and fungal infections without a scientific basis. This work was aimed at screening the phytochemical constituents and evaluating the antifungal properties of methanol leaf extract its ethyl acetate and n-butanol fractions of T. globiferus against some clinical fungal isolates including Candida albicans, Trychophyton mentagrophytes, Trychophyton  rubrum and Aspergillus niger using agar well diffusion and broth micro-dilution techniques.


Methods: Preliminary screening of phytochemical constituents of extract and fractions of T. globiferus indicated the presence of carbohydrates, alkaloids, glycosides, tannins, flavonoids,  saponins, steroids and triterpenes.


Results: The methanol extract and its fractions demonstrated significant (P<0.05) antifungal effect  against all the test organisms with mean zone of inhibition ranging from 27.83±0.16 – 14.46±0.29mm which was higher compared to that of the standard drug, Fluconazole (26.1±0.44 –18.49±0.16 mm). The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the extract ranged between 6.25 – 25.0 mg/mL; ethyl acetate fraction had 3.13 – 25.0 mg/mL while n-butanol fraction had the least MIC ranging from 0.39-12.5 mg/mL against the test organisms.


Conclusion: Study concluded that T. globiferus have good antifungal activity validating the ethnomedicinal claim for the use of the plant in the treating fungal diseases.


Peer Review History:


Received 2 January 2020;   Revised 25 February; Accepted 1 March, Available online 15 March 2020


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Received file


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Average Peer review marks at initial stage: 6.0/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Dr. Gehan Fawzy Abdel Raoof Kandeel


Affiliation: Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt


E-mail: gehankandeel9@yahoo.com


 


Name: Dr. Ali Gamal Ahmed Al-kaf


Affiliation: Sana'a university, Yemen


E-mail: alialkaf21@gmail.com


 


Name: Dr. Mahmut Yıldıztekin


Affiliation: Muğla Sıtkı Koçman University, Turkey


E-mail: mahmutyildiztekin@mu.edu.tr


Comments of reviewer(s):


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Keywords: Antifungal, Phytochemical screening, Tapinanthus globiferus
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How to Cite
Abubakar, H., A. Musa, M. Abdullahi, and A. Yusuf. “ANTIFUNGAL EFFECTS OF TAPINANTHUS GLOBIFERUS GROWING ON VITEXDONIANA AGAINST SOME FUNGAL ISOLATES”. Universal Journal of Pharmaceutical Research, Vol. 5, no. 1, Mar. 2020, doi:https://doi.org/10.22270/ujpr.v5i1.361.
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Research Articles