GREEN, RAPID, SIMPLE, AND AN EFFECTIVE ONE-POT MULTICOMPONENT STRATEGY FOR SYNTHESIS OF NOVEL DIHYDROPYRANO[2,3-C]PYRAZOL-6-AMINES IN AQUEOUS MEDIUM

Abstract

Objectives:  A series of new dihydropyrano [2,3-c]pyrazol-6-amines in this investigation  study, are synthesized  by the strategy of one-pot four component reaction in an aqueous medium.


Methods:  After getting optimum conditions the reaction of different substituted aromatic aldehydes, ethyl acetoacetate, hydrazine hydrate,  and phenylacetonitrile catalysed by Sodium hydrogen sulphate NaHSO4 (0.5 m mol) by refluxing in ethanol-water (1:1) (5 ml) and heated at 80 oC. The synthesized molecules product was filtered, washed with water to get nearly pure product in excellent yield.


Results:  The pure products which were got in a short duration, with excellent yield (80 – 87%). Those new compounds were identified by using spectroscopic techniques FT-IR, 1H-NMR and 13C-NMR.


Conclusion: In conclusion, the usefulness of this one-pot multicomponents protocol include easily available starting materials, facile, simple and environment-friendly procedure, and easier separation of products by filtration.


Peer Review History:


Received 5 March 2019; Revised 11 April; Accepted 9 May, Available online 15 May 2020


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Received file


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Average Peer review marks at initial stage: 5.0/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Name: Prof Cyprian Ogbonna ONYEJI


Affiliation: Obafemi Awolowo University, Ile-Ife, Nigeria


E-mail: conyeji@oauife.edu.ng


 


Name: Dr. Md. Shahidul Islam


Affiliation: USTC, Chittagong, Bangladesh


E-mail: S_i_liton@yahoo.com


Comments of reviewer(s):


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Keywords: Araldehydes, ethyl acetoacetate, fluoro phenylacetonitrile, hydrazine hydrate, pyrano[2,3-c]pyrazol-6-amines, water
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How to Cite
Azzam, S. H. S., A. Siddekha, and M. Pasha. “GREEN, RAPID, SIMPLE, AND AN EFFECTIVE ONE-POT MULTICOMPONENT STRATEGY FOR SYNTHESIS OF NOVEL DIHYDROPYRANO[2,3-C]PYRAZOL-6-AMINES IN AQUEOUS MEDIUM”. Universal Journal of Pharmaceutical Research, Vol. 5, no. 2, May 2020, doi:https://doi.org/10.22270/ujpr.v5i2.383.
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Research Articles