ACORUS CALAMUS L ON TYPE 2 DIABETES MELLITUS MEDICATION
Diabetes is one of the metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Type 2 diabetes, which accounts for ~90–95% of those with diabetes, the cause is a combination of resistance to insulin action and an inadequate compensatory insulin secretory response. Adequate glycemic control is thus one of the key factors to treat and/or reduce the diabetes and many plants have been used to reduce the glucose level by inhibiting the α-glucosidase that breaks down starch and disaccharides to glucose. Acorus calamus L (AC), a folk medicine to treat type 2 diabetes. In vitro α-glucosidase assay were carried out by measuring the release of p-nitrophenol, the insulin sensitizing activity, AC significantly decreased fasting serum glucose, and suppressed the increase of blood glucose levels after 2g/kg glucose loading in normal mice, in silico study showed that chemical compound on AC can inhibit α-glucosidase and the present study is designed to investigate the effects and molecular mechanisms of AC on glucagon-like peptide-1 (GLP-1) expression and secretion related to its hypoglycemic effects.
Peer Review History:
Received 8 January 2020; Revised 9 February; Accepted 1 March, Available online 15 March 2020
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Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.5/10
Name: Dr. Mohamed Said Fathy Al-Refaey
Affiliation: University of Sadat City, Menofia, Egypt
Name: Dr. Gehan Fawzy Abdel Raoof Kandeel
Affiliation: Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt
Comments of reviewer(s):