ACORUS CALAMUS L ON TYPE 2 DIABETES MELLITUS MEDICATION

Abstract

Diabetes is one of the metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Type 2 diabetes, which accounts for ~90–95% of those with diabetes, the cause is a combination of resistance to insulin action and an inadequate compensatory insulin secretory response. Adequate glycemic control is thus one of the key factors to treat and/or reduce the diabetes and many plants have been used to reduce the glucose level by inhibiting the α-glucosidase that breaks down starch and disaccharides to glucose. Acorus calamus L (AC), a folk medicine to treat type 2 diabetes. In vitro α-glucosidase assay were carried out by measuring the release of p-nitrophenol, the insulin sensitizing activity, AC significantly decreased fasting serum glucose, and suppressed the increase of blood glucose levels after 2g/kg glucose loading in normal mice, in silico study showed that chemical compound on AC can inhibit α-glucosidase and the present study is designed to investigate the effects and molecular mechanisms of AC on glucagon-like peptide-1 (GLP-1) expression and secretion related to its hypoglycemic effects.


Peer Review History:


Received 8 January 2020;   Revised 9 February; Accepted 1 March, Available online 15 March 2020


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Received file


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Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Dr. Mohamed Said Fathy Al-Refaey


Affiliation: University of Sadat City, Menofia, Egypt


E-mail: mido_ph212@yahoo.com


 


Name: Dr. Gehan Fawzy Abdel Raoof Kandeel


Affiliation: Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt


E-mail: gehankandeel9@yahoo.com


Comments of reviewer(s):


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Keywords: Acorus calamus L, folk medicine, α-glucosidase, in silico, molecular mechanism, type 2 diabetes
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How to Cite
Najib, A. “ACORUS CALAMUS L ON TYPE 2 DIABETES MELLITUS MEDICATION”. Universal Journal of Pharmaceutical Research, Vol. 5, no. 2, May 2020, doi:https://doi.org/10.22270/ujpr.v5i2.391.
Section
Review Articles