URINARY TRACT INFECTIONS IN POST OPERATIVE PATIENTS: PREVALENCE RATE, BACTERIAL PROFILE, ANTIBIOTIC SENSITIVITY AND SPECIFIC RISK FACTORS

  • Abdulrahman Y. Al-Haifi Department of Microbiology, Faculty of Medicine , Thamar University, Dhamar, Yemen.
  • Abdul Salam Mohamed Al Makdad Department of of Medicine, Faculty of Medicine, Thamar University, Dhamar, Yemen.
  • Mohammed Kassim Salah Department of of Medicine, Faculty of Medicine, Thamar University, Dhamar, Yemen.
  • Hassan A. Al-Shamahy Medical Microbiology and Clinical Immunology Department, Faculty of Medicine and Health Sciences, Sana’a University, Republic of Yemen. https://orcid.org/0000-0001-6958-7012

Abstract

Background and objective: Urinary tract infections (UTIs) are the most common minor complication after operations, mostly due to bladder catheterization that used routinely during operations. This investigation seeks to determine prevalence rate, bacterial features, antibiotic sensitivity and risk factors for urinary tract infection in postoperative patients in tertiary hospitals in Sana’a, Yemen.


Methods: This prospective analysis included 390 patients undergoing surgery between 2017 and 2018 at Al-Thawra Hospital. The study includes 258 male and 132 female between the ages 5 to 80 years. Clinical and demographic data and factors affecting UTIs were collected in the standard questionnaire, and the sample was obtained after catheter removal; or, in patients with a clinical indication of continuous catheterization, a sample was obtained after the replacement of a new catheter. The samples were cultured, examined for significant possible bacterial pathogens, isolated and identified by standard laboratory techniques, and microbial sensitivity testing was carried out by disc diffusion method. The operative characteristics associated with postoperative UTI were also analysis.


Results: Postoperative UTI (POUTI) occurred in 144/390 (37%), and the predominant post-operative uropathogen was Escherichia coli (34%), followed by Pseudomonas aeruginosa 1(27%) and Staphylococcus coagulase negative (16.7%). In Gram-negative bacteria, high resistance to ampicillin (95%), nalidixic acid (63%), ceftriaxone (68%) and cotrimoxazole (55%) was recorded, while high sensitivity to amikacin (98%) and ciprofloxacin. (84%), cefotaxime (87%), gentamicin (87%) and imipenem (98%). In Gram-positive bacteria, high resistance to penicillin (90%), erythromycin (85%), and amoxicillin (78%) was recorded, while high sensitivity to aztreonam (94%), augmentin (83%),   ciprofloxacin (93%), cefotaxime (86%), gentamicin (85%), Rifampicin (100%) and vancomycin (97%).  The following characteristics are independently associated with postoperative UTI: female sex (OR 2.1, 95% CI 1.3–3.2), Rubber PTFE catheter (OR 4.7, 95% CI 1.99–11.4), longer duration of catheterization >10 days (OR 4.4, 95% CI 2.3–8.3), overweight (OR 1.7, 95% CI 1.1–2.9), and emergency surgery  (OR 1.9, 95% CI 1.2–3.0).


Conclusions: POUTI remains an important problem in our hospitals and what complicates the situation is that all the causative microorganisms are MDR with few treatment options; and several risk factors were independently associated with POUTI.


Peer Review History:


Received 14 May 2020; Revised 15 June; Accepted 1 July, Available online 15 July 2020


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Received file


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Average Peer review marks at initial stage: 6.0/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Name: Dr. Amany Mohamed Alboghdadly


Affiliation: Princess Nourah bint abdulrahman university, Riyadh


E-mail: amalbgadley@pnu.edu.sa


 


Name: Dr. A.A. Mgbahurike


Affiliation: University of Port Harcourt, Nigeria


E-mail: amaka_mgbahurike@yahoo.com


 


Name: Dr. Asia Selman Abdullah


Affiliation: Al-Razi university, Department of Pharmacy, Yemen


E-mail: asia_abdullah65@yahoo.com


 


Comments of reviewer(s):


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How to Cite
Al-Haifi, A. Y., A. S. M. Al Makdad, M. K. Salah, and H. A. Al-Shamahy. “URINARY TRACT INFECTIONS IN POST OPERATIVE PATIENTS: PREVALENCE RATE, BACTERIAL PROFILE, ANTIBIOTIC SENSITIVITY AND SPECIFIC RISK FACTORS”. Universal Journal of Pharmaceutical Research, Vol. 5, no. 3, July 2020, doi:https://doi.org/10.22270/ujpr.v5i3.411.
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Research Articles

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