PREPARATION AND CHARACTERIZATION OF TOLTERODINE TARTRATE PRONIOSOMES

Abstract

Objective: Proniosomes are dry free flowing, granular products that are water soluble carrier particles, coated with surfactants and can be hydrated to form niosomal dispersion immediately before use in hot aqueous media. Tolterodine, is medication used to treat frequent urination, urinary incontinence, or urinary urgency. It acts on M2 and M3 subtypes of muscarinic receptors.


Methods: Tolterodine tartrate proniosome formulations were prepared by coacervation phase separation method by using different surfactants in different ratios.  The prepared proniosomal formulations were evaluated for vesicle size, rate of spontaneity, encapsulation efficiency, drug content, In vitro release study and stability studies.


Results: The size range was found to be 15.28±0.33 to 16.43±0.22 µm. Viscosity of all formulations lies in the range of 7244-9314 cp. Maximum release was shown by formulations of batch PG4 (87.45 %), and minimum for formulations of batch PG4 (50%), after 12 h. Optimized formulations PG4 shows stability at different temperatures.


Conclusion: Tolterodine tartrate proniosome formulations prepared by using coacervation phase separation method are capable of releasing drug for the extended period of time.


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Peer Review History:


Received 2 April 2017;   Revised 5 May; Accepted 10 May, Available online 15 May 2017


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Received file


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Average Peer review marks at initial stage: 3.0/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab


Affiliation: Umm Al-Qura University;  Makkah Al-Mukarramah, Saudi Arabia


E-mail: maabourehab@uqu.edu.sa


 


Name: Dr. Sally A. El-Zahaby


Affiliation: Pharos University in Alexandria, Egypt


E-mail: sally.elzahaby@yahoo.com


Comments of reviewer(s):


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Keywords: Tolterodine tartrate, proniosome, Span 60, Tween 40, in vitro release
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How to Cite
Ugochukwu, A., O. Nnedimkpa, and N. Rita. “PREPARATION AND CHARACTERIZATION OF TOLTERODINE TARTRATE PRONIOSOMES”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 2, Mar. 2017, doi:https://doi.org/10.22270/ujpr.v2i2.R1.
Section
Research Articles