COMPARISON BETWEEN THE EFFECTS OF THYMOQUINONE OBTAINED FROM THE SEEDS OF NIGELLA SATIVA AND VERAPAMIL ON THE VOLUME AND ACIDITY OF GASTRIC ACID SECRETION

  • Rahma Hamayun College of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia.
  • Muhammad Jan College of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia.
  • Muhammad Fazeel University of Agriculture, Pakistan

Abstract

Background and Objectives: The over production of gastric acid results in peptic ulcer. This study was done to compare the effects of thymoquinone and Verapamil on volume and acidity of carbachol induced gastric secretion.


Methods: There were 24 rabbits used, weighing 1-1.5 kg. The rabbits were kept on fasting for 48 hours. After fasting, the pylorus of each rabbit was ligated. Thymoquinone 5 mg/kg, Carbachol 600mg/kg and Verapamil 10 mg/kg body weight were administered intraperitoneally. Pylorus ligation method was used for getting gastric contents and titration method was used for finding out acidity.


Results: Verapamil has been proved very effective for the treatment of many diseases. The drug verapamil inhibits the release of histamine, acetylcholine and gastrin. Verapamil has also shown effects in reducing the secretion of gastric acid. It was found that Thymoquinone reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P=0.000) but when we compared the results of Thymoquinones with that of Verapamil, it was non-significant.


Conclusions:   It was concluded that Thymoquinone can be used for the treatment of peptic ulcer and all other diseases which are caused by increased gastric acidity like dyspepsia, gastritis and reflux esophagitis.


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Peer Review History:


Received 8 July 2020; Revised 14 August; Accepted 6 September, Available online 16 September 2020


Academic Editor: Dr. Muhammad Zahid Iqbalorcid22.jpg, AIMST University, Malaysia, drmmziqbal@gmail.com


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Received file:blue_23983.gif                Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 6.0/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Dr. Hatem Sameir Abbasorcid2.jpg, Al-Azhar University, Egypt, hsam8406@yahoo.com


Prof. Dr. Ali Gamal Ahmed Al-kaforcid2.jpg, Sana'a university, Yemen, alialkaf21@gmail.com


Dr. Gehan Fawzy Abdel Raoof Kandeelorcid2.jpg, National Research Centre, Egypt, gehankandeel9@yahoo.com


Dr. Mahmut Yıldıztekinorcid2.jpg, Muğla Sıtkı Koçman University, Turkey, mahmutyildiztekin@mu.edu.tr


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Keywords: Gastric secretion, Thymoquinone, Verapamil

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How to Cite
Hamayun, R., M. Jan, and M. Fazeel. “COMPARISON BETWEEN THE EFFECTS OF THYMOQUINONE OBTAINED FROM THE SEEDS OF NIGELLA SATIVA AND VERAPAMIL ON THE VOLUME AND ACIDITY OF GASTRIC ACID SECRETION”. Universal Journal of Pharmaceutical Research, Vol. 5, no. 4, Sept. 2020, doi:https://doi.org/10.22270/ujpr.v5i4.453.
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Research Articles