• Edenta Chidi Department of biochemistry, Renaisance University, Enugu, Nigeria
  • Nwobodo Ndubuisi Nwobodo Department of Pharmacology & Therapeutics, Division of Clinical Pharmacology and Translational Medicine, University of Science and Technology, Enugu, Enugu State
  • Nweje-Anyalowu Paul C Clifford University, Owerrinta, Abia State, Nigeria


Objective: Gongronema latifolium (Asclepiadiaceae) is used as bitter spice or flavouring agent in many traditional Nigerian dishes. It is well known for medicinal and nutritional purposes like anti-hyperglycemic, anti-oxidant, antitussive and widely distributed in the southeastern states of Nigeria. Objective of present study was to evaluate the anti-hyperglycemic and anti-oxidant effect of the methanol extract of Gongronema latifolium leaves.

Methods: The methanol extract of G. latifolium at doses of 250 and 500 mg/kg were studied for anti-hyperglycemic effect in alloxan-induced hyperglycemic rats. The variation in blood glucose level in normal and experimental rats on 0, 7, 14 and 21 days of treatment has also been recorded. The effect of different treatment on body weight of rats was also determined. The antioxidant properties of the extracts as determined by the DPPH free radical scavenging assay.

Results: Treatment with G. latifolium extract showed signs of recovery as comparable with the standard drug glibenclamide (0.25 mg/kg). The result showed that G. latifolium extract caused a concentration dependent percentage increase of antioxidant activity.

Conclusion: Study concludes that methanol leaf extract of G. latifolium possesses significant anti-hyperglycemic and anti-oxidant activities.


Peer Review History:

Received 1 April 2017;   Revised 12 May; Accepted 13 May, Available online 15 May 2017

Academic Editor: Dr. Emmanuel O. Olorunsolaorcid22.jpg, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria,

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Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif

Average Peer review marks at initial stage: 4.0/10

Average Peer review marks at publication stage: 7.5/10

Reviewer(s) detail:

Dr. Heba M. Abd El-Azimorcid22.jpg, Damanhour University, Egypt,

Dr. Leyla Açıkorcid22.jpg, Gazi University, Ankara, Turkey,

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Keywords: Gongronema latifolium, anti-hyperglycemic, anti-oxidant, carrageenan-induced paw edema.


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How to Cite
Chidi, E., N. Nwobodo, and N.-A. C. “ANTI-HYPERGLYCEMIC AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF GONGRONEMA LATIFOLIUM”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 2, Mar. 2017, doi:
Research Articles