DEVELOPMENT AND IN-VITRO EVALUATION OF MATRIX-TYPE TRANSDERMAL PATCHES OF LOSARTAN POTASSIUM

  • Fatima A . Adamude Department of Biochemistry, Federal University Lafia, Nigeria
  • Uhama Kingsley Chukwuka Department of Biochemistry, Anambra State University Uli, Nigeria

Abstract

Objective: Since last decade drugs through skin has received great attention of many researchers. The aim of present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of Losartan potassium.


Methods: Four transdermal patches formulations of Losartan potassium were prepared by using different polymers using blends of different polymers like polyvinylpyrrolidone K30 (PVP K30) and ethylcellulose (EC), hydroxypropyl methyl cellulose and chitosan. Physical studies including thickness, folding endurance moisture content, tensile strength and flatness were performed on all formulations. In-vitro diffusion study of 10 hrs was performed by means of Franz diffusion cell.


Results: Thickness of four prepared patches lies in the range of 0.30 to 0.33 mm. Percent moisture content was found to be in the range of 2.56 to 3.44. The cumulative percent drug release after 10 hrs in between 38.41 to 80.41%.


Stability study performed on selective batch, TP1 for 12 weeks at different temperature indicates stability of transdermal patches at room temperature.


Conclusion:Present study concluded that Losartan potassium can be formulated into the transdermal matrix type patches to sustain its release characteristics. Polymeric composition of batch TP1 (PVP K30: Chitosan: 70:30) was found to be the best choice for manufacturing transdermal patches of Losartan potassium among the formulations studied.


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Peer Review History:


Received 2 April 2017;   Revised 12 May; Accepted 13 May, Available online 15 May 2017


Academic Editor: 


Dr. A.A. Mgbahurikeorcid22.jpg, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com


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Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Asmaa Ahmed Mohamed Ahmed Khalifaorcid22.jpg, Pharos University, Alexandria, Egypt, asmaa.khalifa@pua.edu.eg


Dr. Dalia Kamal Zaffar Aliorcid22.jpg, Modern University for technology and information, Egypt, dr.moda88@gmail.com


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DEVELOPMENT AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF PIOGLITAZONE HYDROCHLORIDE

Keywords: Losartan potassium, skin, transdermal drug delivery system, Franz diffusion cell, in-vitro diffusion

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How to Cite
Adamude, F., and U. Chukwuka. “DEVELOPMENT AND IN-VITRO EVALUATION OF MATRIX-TYPE TRANSDERMAL PATCHES OF LOSARTAN POTASSIUM”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 2, Mar. 2017, doi:https://doi.org/10.22270/ujpr.v2i2.R5.
Section
Research Articles