EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL

  • M. Salim Mirza Research Scholar, Faculty of Pharmacy, Pacific University, Udaipur, Rajasthan, India https://orcid.org/0000-0003-4185-1269
  • Sayed Ayaz Ali Associate Professor, Dept.of Pharmacology, Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India https://orcid.org/0000-0001-8685-6763
  • Indrajeet Sanghvi Dean, Faculty of Pharmacy, Pacific University, Udaipur, Rajasthan, India

Abstract

Objective: The present study is undertaken to evaluate the effect of Euphorbia neriifolia stem bark on blood glucose and lipid levels in experimental diabetic rats.


Methods: Methanolic extract of Euphorbia neriifolia stem bark (MEEN) was administered at different doses and its effect on blood glucose, haemoglobin, serum and tissue lipids, hexokinase and glucose-6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug.


Results: Euphorbia neriifolia methanolic extract (MEEN), at doses of 100,200 and 400mg/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Euphorbia neriifolia at 400mg/kg was found to be comparable to glibenclamide.


Conclusion: The study indicates that the Euphorbia neriifolia possess antihyperlipidaemic effect as well as antidiabetic activity.


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Peer Review History:


Received 19 June 2017;   Revised 25 June; Accepted 1 July, Available online 15 July 2017


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Received file


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Average Peer review marks at initial stage: 5.0/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Dr. Mohamed Derbali


Affiliation: Faculty of Pharmacy, Monastir, Tunisia


E-mail: mohamed.edderbali@gmail.com


 


Name: Dr. Sabah Hussien El-Ghaiesh


Affiliation: Tanta University, Egypt


E-mail: s.ghaiesh@gmail.com


Comments of reviewer(s):


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Keywords: Blood glucose, Euphorbia neriifolia, Carbohydrate enzymes, Insulin, Lipids
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How to Cite
Mirza, M., S. Ali, and I. Sanghvi. “EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 3, May 2017, doi:https://doi.org/10.22270/ujpr.v2i3.R1.
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Research Articles