EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL

  • M. Salim Mirza Research Scholar, Faculty of Pharmacy, Pacific University, Udaipur, Rajasthan, India
  • Sayed Ayaz Ali Associate Professor, Dept.of Pharmacology, Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India
  • Indrajeet Sanghvi Dean, Faculty of Pharmacy, Pacific University, Udaipur, Rajasthan, India

Abstract

The present study is undertaken to evaluate the effect of Euphorbia neriifolia stem bark on blood glucose and lipid levels in experimental diabetic rats. Methanolic extract of Euphorbia neriifolia stem bark (MEEN) was administered at different doses and  its  effect on blood glucose, haemoglobin, serum and tissue lipids, hexokinase and glucose-6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug. Euphorbia neriifolia Methanolic extract (MEEN), at doses of 100,200 and 400mg/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Euphorbia neriifolia at 400mg/kg was found to be comparable to glibenclamide. The study indicates that the Euphorbia neriifolia possess antihyperlipidaemic effect as well as antidiabetic activity.

Keywords: Blood glucose, Euphorbia neriifolia, Carbohydrate enzymes, Insulin, Lipids
Statistics
97 Views | 97 Downloads
How to Cite
Mirza, M., S. Ali, and I. Sanghvi. “EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 3, May 2017, doi:https://doi.org/10.22270/ujpr.v2i3.R1.
Section
Research Articles