EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL
Objective: The present study is undertaken to evaluate the effect of Euphorbia neriifolia stem bark on blood glucose and lipid levels in experimental diabetic rats.
Methods: Methanolic extract of Euphorbia neriifolia stem bark (MEEN) was administered at different doses and its effect on blood glucose, haemoglobin, serum and tissue lipids, hexokinase and glucose-6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug.
Results: Euphorbia neriifolia methanolic extract (MEEN), at doses of 100,200 and 400mg/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Euphorbia neriifolia at 400mg/kg was found to be comparable to glibenclamide.
Conclusion: The study indicates that the Euphorbia neriifolia possess antihyperlipidaemic effect as well as antidiabetic activity.
Peer Review History:
Received 19 June 2017; Revised 25 June; Accepted 1 July, Available online 15 July 2017
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Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.5/10
Name: Dr. Mohamed Derbali
Affiliation: Faculty of Pharmacy, Monastir, Tunisia
Name: Dr. Sabah Hussien El-Ghaiesh
Affiliation: Tanta University, Egypt
Comments of reviewer(s):