DEVELOPMENT AND EVALUATION OF IN SITU GELLING GASTRORETENTIVE FORMULATIONS OF MELOXICAM
The aim of this study was to develop a novel gastro retentive oral floating in situ gelling system for controlled release of Meloxicam. Meloxicam is a NSAID that inhibits cyclooxygenase (COX) synthesis and has analgesic and antipyretic effects. Four polymer based floating in situ gelling systems of Meloxicam were prepared by dissolving varying concentrations of different ingredients including sodium alginate, HPMC K100M, calcium carbonate, sodium citrate. The prepared gels were characterized for solution viscosity, pH, gelling capacity, floating lag time, floating duration and in-vitro release study. All the formulations showed instant gelation maintaining integrity for at least 12 h. The study demonstrated that a stomach specific in-situ gel of Meloxicam could be prepared using the floating mechanism to increase the residence time of the drug in the stomach and improve bioavailability and thus improve patient compliance.
Peer Review History:
Received 1 June 2017; Revised 11 July; Accepted 12 July, Available online 15 July 2017
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Average Peer review marks at initial stage: 4.5/10
Average Peer review marks at publication stage: 7.0/10
Name: Dr. Wilman Ismael Carrillo Terán
Affiliation: Technical University of Ambato Avda, Ecuador
Name: Dr. Maha Khalifa Ahmed Khalifa
Affiliation: Al-Azhar Universit - Cairo, Egypt
Comments of reviewer(s):