SOLID DISPERSION TECHNOLOGY, A CONTEMPORARY OVERVIEW ON A WELL ESTABLISHED TECHNIQUE

  • Mahmoud A. Younis Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Abstract

Solubility is a significant physicochemical parameter that affects the absorption, bioavailability and therapeutic effectiveness of any drug. Formulation development would fail if drug has a poor aqueous solubility. The low aqueous solubility of drug substances will lead to inadequate absorption and consequently, low bioavailability. Improvement of the aqueous solubility and dissolution rate of hydrophobic drugs remains one of the most difficult challenges in drug development process. Among various techniques used to improve poor aqueous solubility of drugs, solid dispersion technology has been extensively used in the literature and has become one of the well-established pharmaceutical procedures during formulation process. Although the technique seems to be “a part of the past”, literature tells us that it is still used and developed to suit current needs of pharmaceutical industry. This review article highlights recent advances in solid dispersion technology and its applications in contemporary pharmaceutical research.


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Peer Review History:


Received 17 June 2017;   Revised 25 June; Accepted 1 July, Available online 15 July 2017


Academic Editor: 


Dr. A.A. Mgbahurikeorcid22.jpg, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com


UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.


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Average Peer review marks at initial stage: 6.0/10


Average Peer review marks at publication stage: 8.0/10


Reviewer(s) detail:


Dr. Jennifer Audu-Peterorcid22.jpg, University of Jos, Nigeria, drambia44@gmail.com


Dr. Mohammed Abdel-Wahab Sayed Abourehaborcid22.jpg, Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia, mohawahab2002@yahoo.com


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This article has been cited by:


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Keywords: Dissolution rate, hydrophilic carriers, poorly-soluble drugs, solid dispersion, solubility

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How to Cite
Younis, M. “SOLID DISPERSION TECHNOLOGY, A CONTEMPORARY OVERVIEW ON A WELL ESTABLISHED TECHNIQUE”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 3, May 2017, doi:https://doi.org/10.22270/ujpr.v2i3.RW1.
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Review Articles