GLAUCOMA: SECRETS OF SILENT THIEF OF VISION – A REVIEW

  • Oyeniran Taiwo Opeyemi Department of Biochemistry, University of Ibadan, Nigeria

Abstract

Glaucoma has been highlighted as a priority eye disease by the World Health Organization’s global initiative to eliminate avoidable blindness by the year 2020. Glaucoma is defined as an optic neuropathy, characterized for loss of visual field and injury of the optic nerve. However the mechanism leading to the disease is still unclear. Factors that are responsible for it include glutamate-induced neurotoxicity, nitric oxide based damage, disruption of neurotrophic factor transport and immune-induced neuro destruction. At present treatment options primarily aim at decreasing intra-ocular pressure (IOP) by utilizing pharmacological agents, laser therapy and surgery. Gaining a better understanding of the pathogenesis can aid in the development of new treatment options and, perhaps, even a cure for glaucoma. Since there is no cure for Glaucoma, early detection and treatment can slow or prevent further vision lossThis article discusses the pathophysiology of glaucoma, its detection, diagnosis monitoring and treatment.

Keywords: Glaucoma, neuropathy, glutamate-induced neurotoxicity, intra-ocular pressure
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