Glaucoma has been highlighted as a priority eye disease by the World Health Organization’s global initiative to eliminate avoidable blindness by the year 2020. Glaucoma is defined as an optic neuropathy, characterized for loss of visual field and injury of the optic nerve. However the mechanism leading to the disease is still unclear. Factors that are responsible for it include glutamate-induced neurotoxicity, nitric oxide based damage, disruption of neurotrophic factor transport and immune-induced neuro destruction. At present treatment options primarily aim at decreasing intra-ocular pressure (IOP) by utilizing pharmacological agents, laser therapy and surgery. Gaining a better understanding of the pathogenesis can aid in the development of new treatment options and, perhaps, even a cure for glaucoma. Since there is no cure for Glaucoma, early detection and treatment can slow or prevent further vision lossThis article discusses the pathophysiology of glaucoma, its detection, diagnosis monitoring and treatment.


Peer Review History:

Received 2 June 2017;   Revised 6 July; Accepted 9 July, Available online 15 July 2017

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Received file


Average Peer review marks at initial stage: 3.5/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Name: Dr. Emmanuel O. Olorunsola

Affiliation: Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria



Name: Dr. Heba M. Abd El-Azim

Affiliation: Damanhour University, Egypt


Comments of reviewer(s):



Keywords: Glaucoma, neuropathy, glutamate-induced neurotoxicity, intra-ocular pressure
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