DENDRIMERS: A NOVEL TOOL FOR DRUG DELIVERY AND TARGETING

Abstract

Dendrimers are hyper-branched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers. Due to their unique architecture these have improved physical and chemical properties like high solubility, miscibility and reactivity.  Dendrimers consist of well defined size, shape, molecular weight and monodispersity. These properties formulate the dendrimers a suitable carrier in drug delivery application. These are built from number of molecular entities of colloidal particles that exists in equilibrium with the molecules or ions in nature and due to these increases the solubility of poorly soluble drugs. Dendrimers have the ability to encapsulate and bind the guest molecule can be used for solubility enhancement, sustained release and various drug delivery applications. The terminal groups are modified to attach biologically active substances for targeting purpose. Dendrimers are suitable for a wide range of targeted drug delivery, controlled drug delivery, gene delivery and industrial applications. This review gives concise information about the dendrimers, its synthesis, characterization and application in drug delivery.


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Peer Review History:


Received 9 June 2017;   Revised 4 July; Accepted 9 July, Available online 15 July 2017


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Received file


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Average Peer review marks at initial stage: 4.5/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Name: Areen Alshweiat


Affiliation: University of Szeged, Hungary


E-mail: areen.alshweiat@hu.edu.jo


 


Name: Dr. Liliya Logoyda


Affiliation: Horbachevsky Ternopil State Medical University, Ukraine


E-mail: logojda@tdmu.edu.ua


Comments of reviewer(s):


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Keywords: Dendrimers, monomers, solubility enhancement, drug delivery
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How to Cite
Chigbo, U., A. Ugochukwu, and D. John. “DENDRIMERS: A NOVEL TOOL FOR DRUG DELIVERY AND TARGETING”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 3, May 2017, doi:https://doi.org/10.22270/ujpr.v2i3.RW5.
Section
Review Articles