• Udokwu Japhet Chigbo Department of Biochemistry, Ahmadu Bello University Teaching Hospital Zaria, Nigeria.
  • Adim Ekene Ugochukwu Department of Biochemistry, Ahmadu Bello University Teaching Hospital Zaria, Nigeria.
  • Dingwoke Francis John Department of Biochemistry, Ahmadu Bello University Teaching Hospital Zaria, Nigeria.


Dendrimers are hyper-branched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers. Due to their unique architecture these have improved physical and chemical properties like high solubility, miscibility and reactivity.  Dendrimers consist of well defined size, shape, molecular weight and monodispersity. These properties formulate the dendrimers a suitable carrier in drug delivery application. These are built from number of molecular entities of colloidal particles that exists in equilibrium with the molecules or ions in nature and due to these increases the solubility of poorly soluble drugs. Dendrimers have the ability to encapsulate and bind the guest molecule can be used for solubility enhancement, sustained release and various drug delivery applications. The terminal groups are modified to attach biologically active substances for targeting purpose. Dendrimers are suitable for a wide range of targeted drug delivery, controlled drug delivery, gene delivery and industrial applications. This review gives concise information about the dendrimers, its synthesis, characterization and application in drug delivery.


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Peer Review History:

Received 9 June 2017;   Revised 4 July; Accepted 9 July, Available online 15 July 2017

Academic Editor: Dr. Emmanuel O. Olorunsolaorcid22.jpg, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria,

UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.

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Average Peer review marks at initial stage: 4.5/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Dr. Areen Alshweiatorcid22.jpg, University of Szeged, Hungary,

Dr. Liliya Logoydaorcid22.jpg, Horbachevsky Ternopil State Medical University, Ukraine,

This article has been cited by:

Awad, Linh I and N. Jber. “Synthesis of Dendrimers Liquid Crystalline Materials based on 1,3,5-triphenylbenzene.” Journal of drug delivery 9 (2019): n. pag. Pubmed

Keywords: Dendrimers, monomers, solubility enhancement, drug delivery


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How to Cite
Chigbo, U., A. Ugochukwu, and D. John. “DENDRIMERS: A NOVEL TOOL FOR DRUG DELIVERY AND TARGETING”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 3, May 2017, doi:
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