HYPOGLYCEMIC AND LIPID LOWERING EFFECT OF AQUEOUS FRESH LEAF EXTRACT OF CHROMOLAENA ODORATA (LINN) IN ALBINO WISTAR RATS FED DIFFERENT CONCENTRATIONS OF CHOLESTEROL ENRICHED DIET

  • Idoko A Department of Biochemistry, Faculty of Natural Sciences Caritas University Amorji – Nike, P.M.B. 01784, Enugu, Nigeria.
  • Ikpe VPO Department of Biochemistry, Faculty of Natural Sciences Caritas University Amorji – Nike, P.M.B. 01784, Enugu, Nigeria.
  • Rita ON Department of Biochemistry, Faculty of Natural Sciences Caritas University Amorji – Nike, P.M.B. 01784, Enugu, Nigeria.
  • Nelson NO Department of Biochemistry, Faculty of Natural Sciences Caritas University Amorji – Nike, P.M.B. 01784, Enugu, Nigeria.
  • Effiong JU Department of Biochemistry, Faculty of Natural Sciences Caritas University Amorji – Nike, P.M.B. 01784, Enugu, Nigeria.
  • Alhassan AJ Department of Biochemistry, Faculty of Basic Sciences, Bayero University, P.M.B. 3011, Kano, Nigeria.
  • Muhammad IU Department of Biochemistry, Faculty of Basic Sciences, Bayero University, P.M.B. 3011, Kano, Nigeria.
  • Abubakar N Department of Biochemistry, Faculty of Sciences, Federal University Dutse, P.M.B. 7156, Jigawa State, Nigeria.
  • Abubakar SM Department of Biochemistry, Faculty of Basic Sciences, Bayero University, P.M.B. 3011, Kano, Nigeria
  • Ugwudike PO Department of Biochemistry, Faculty of Natural Sciences Caritas University Amorji – Nike, P.M.B. 01784, Enugu, Nigeria.

Abstract

Objectives:  High lipids and carbohydrate have been seriously implicated to cardiovascular problems, which has led to several uses of medicinal plants for traditional remedies. The present study investigated the lipid lowering activity of fresh leaf extract of Chromolaena odorata in Albino wistar rats.


Methods: Twenty (20) rats used for the study were grouped into four groups of five (5) rats each. Group I served as normal control, group II, III and IV served as test groups, fed 75, 108 and 148 g of cholesterol enriched diet for one week and thereafter, administered with 50, 100 and 150 mg/kg body weight of fresh leaf extract of Chromolaena odorata respectively for four (4) days. Lipid profile and blood glucose were assayed at fed state and after administration. Results showed a significant (p<0.05) increase in total cholesterol, triacylglycerol, low density lipoprotein, blood glucose concentration and body weight compared with control group in fed state. 


Results: Administration with fresh leaf extract of Chromolaena odorata showed a significant (p<0.05) increase in high density lipoprotein, significant (p<0.05) decrease in blood glucose concentration, low density lipoproteins, triacylglycerol, total cholesterol and body weight of rats. The oral treatment with 50, 100 and 150 mg/kg body weight of the fresh leaf extract of this study demonstrated a general hypoglycemic and hypolipidemic activity not necessary a dose dependent pattern.


Conclusion: It may therefore be concluded that the hypoglycemic and hypolipidemic activity of Chromolaena odorata taken freshly squeezed could be due to its phytochemical and antioxidants content. 


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Peer Review History:


Received 24 February 2018;   Revised 3 March; Accepted 8 March, Available online 15 March 2018


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Received file


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Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Name: Dr. Adebayo Gege Grace Iyabo 


Affiliation: University of Ibadan, Nigeria


E-mail: funbimbola@gmail.com


Comments of reviewer(s):


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This article has been cited by:


Ndife, Joel et al. “Development and comparative evaluation of green and black tisanes using scent leaves (Chromolaena odorata).” Journal of Food Science 3 (2019): 448-455. Pubmed

Keywords: Blood glucose concentration, cholesterol, Chromolaena odorata, hyperlipidemia, hypoglycemic, weight loss
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How to Cite
A, I., I. VPO, R. ON, N. NO, E. JU, A. AJ, M. IU, A. N, A. SM, and U. PO. “HYPOGLYCEMIC AND LIPID LOWERING EFFECT OF AQUEOUS FRESH LEAF EXTRACT OF CHROMOLAENA ODORATA (LINN) IN ALBINO WISTAR RATS FED DIFFERENT CONCENTRATIONS OF CHOLESTEROL ENRICHED DIET”. Universal Journal of Pharmaceutical Research, Vol. 3, no. 1, Apr. 2018, doi:https://doi.org/10.22270/ujpr.v3i1.R7.
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Research Articles