DESIGN AND EVALUATION OF CHRONOTHERAPEUTIC PULSATILE DRUG DELIVERY SYSTEM OF CILNIDIPINE

Abstract

At present scenario the drug regimen based on circadian rhythm is recently gaining much attention worldwide by researchers. Justification behind it is that, there are various diseases like asthma, hypertension, and arthritis show circadian variation that demand time scheduled drug release for effective drug action. A chronodelivery system, based on biological rhythms, is a state-of the- art technology for drug delivery. The aim of present work is formulate and evaluate a press coated pulsatile release tablets of Cilnidipine using an admixture of hydrophilic polymer i.e. hydroxypropyl methyl cellulose (HPMC) and pH sensitive polymers (ethyl cellulose, eudragit S-100) in order to achieve a predetermined lag time for chronopharmacotherapy of Hypertension. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function used for the treatment of hypertension. The tablets prepared were evaluated for different properties like bulk density, tapped density, Angle of repose and Carr’s index), hardness, thickness, weight variation, friability, drug content uniformity and in vitro drug release study.


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Peer Review History:


Received 19 October 2017;   Revised 28 October; Accepted 5 November, Available online 15 November 2017


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Received file


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Average Peer review marks at initial stage: 4.5/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Name: Dr. Vinay Chawla


Affiliation: Rajiv Academy for Pharmacy, Mathura, UP, India


E-mail: drvineychawla@gmail.com


 


Name: Dr. Barkat Ali Khan


Affiliation: Kampala International University, Uganda


E-mail: barki.gold@gmail.com


Comments of reviewer(s):


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Keywords: Chronotherapy, pulsatile, hypertension, circadian variation, press coated tablets
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How to Cite
C, N.-A., A. A, and W. Jim. “DESIGN AND EVALUATION OF CHRONOTHERAPEUTIC PULSATILE DRUG DELIVERY SYSTEM OF CILNIDIPINE”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 5, Sept. 2017, doi:https://doi.org/10.22270/ujpr.v2i5.R4.
Section
Research Articles