DEVELOPMENT AND EVALUATION OF FAST DISSOLVING THIN FILMS OF ARIPIPRAZOLE
Objectives: Aripiprazole, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder and it undergoes extensive hepatic metabolism. The aim of the current study was to develop thin films of Ariprazole to avoid its hepatic metabolism.
Methods: In the present research, five different rapidly dissolving films of Aripiprazole were prepared successfully by using different polymers by means of solvent casting method. The prepared films were evaluated for different parameters including thickness, mass uniformity, pH, folding endurance, drug content uniformity, cumulative percent release, in-vitro dissolution test and accelerated stability studies. Drug release kinetics of the films, the data obtained were fitted to various kinetic equations
Results: The thicknesses of the films were ranged in between 0.15±0.14mm to 0.20±0.09mm and weight in the range 41.3±0.68 to 47.6±0.83mg. The disintegration time of the films were found to be from 19±0.48 to 24±0.52seconds. Formulation of batch F4 has shown maximum release 95.48% in 30 minutes. There was no significant change in appearance, pH, folding endurance, drug content, in vitro disintegration and percentage drug release during stability testing.
Conclusion: Study concludes effective delivery of Aripiprazole in the form of fast dissolving thin films. On the basis of different evaluated parameters formulation of batch F4 was found to be optimum formulation.
Peer Review History:
Received 3 November 2017; Revised 8 November; Accepted 12 November, Available online 15 November 2017
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Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab
Affiliation: Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia
Name: Robert Tungadi
Affiliation: State University of Gorontalo, Indonesia
Comments of reviewer(s):