TY - JOUR AU - Alyahawi, Ali AU - Alkaf, Ali AU - Alnamer, Rashad AU - Alnosary, Taha PY - 2018/11/15 Y2 - 2024/03/29 TI - STUDY OF RESISTANCE FOR RECENTLY MARKETED CARBAPENEM DRUG AMONG HOSPITALISED PATIENTS IN SANA'A, YEMEN JF - Universal Journal of Pharmaceutical Research JA - Univ J Pharm Res VL - 3 IS - 5 SE - Research Articles DO - 10.22270/ujpr.v3i5.203 UR - https://ujpr.org/index.php/journal/article/view/203 SP - AB - <p><strong>Objective:  </strong>Carbapenem resistance is a major and a future public health problem globally. It occurs mainly among Gram-negative bacteria.  Meropenem is the recently marketed carbapenem drug in Yemen. However, recent emergence of carbapenem-resistant isolates has become a major healthcare concern. The current study was designed to estimate the prevalence of meropenem resistance among hospitalised patients in Sana'a, Yemen.</p><p><strong>Methods: </strong>The study was performed at a local hospital in Sana’a, Yemen. The records of Meropenem susceptibility were taken for hospitalised patients. A total of 443 Meropenem susceptibility samples were collected from August, 2017 to July, 2018. The meropenem susceptibility was studied against several isolated pathogens.</p><p><strong>Results: </strong>Out of 443 study sample, 316 (71.3%) were meropenem sensitive isolates and 25.3% of samples were resistant. The <em>Escherichia coli isolates</em> were observed in 27.5% of sample, followed by <em>Pseudomonas aeruginosa</em> (19.6%). 36.4% of total meropenem sensitive isolates (115/316) were <em>Escherichia coli</em>. 82.4% (42/51) of <em>Klebsiella pneumonia</em> isolates were meropenem sensitive and 32.2% (28/87) of <em>Pseudomonas aeruginosa</em> were meropenem resistance. In the present study, 34.5% (109/316) of meropenem sensitive isolates were from blood cultures, followed by sputum cultures (23.7%; 75/316). However, 58% (65/112) of sputum culture isolates were meropenem resistance<strong>.</strong></p><p><strong>Conclusion: </strong>This study concluded that the percentage of resistance to meropenem was high (25.3%) and cannot be neglected. Continued surveillance to closely monitor trends as well as infection control and antibiotic stewardship activities are necessary to preserve treatment options. A more careful monitoring for use of broad-spectrum antibiotics should be instituted.</p><p><img src="https://www.ujpr.org/public/site/images/editor/99.JPG" /></p><p><strong>Peer Review History: </strong></p><p><strong>Received</strong> 4 August 2018; <strong>Revised</strong> 12 September; <strong>Accepted</strong> 28 October, <strong>Available online</strong> 15 November 2018</p><p style="text-align: justify;"><strong>Academic Editor: </strong><strong>Dr. Jennifer Audu-Peter<a href="https://orcid.org/0000-0002-3234-0347" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/editor/orcid22.jpg" /></a></strong>, University of Jos, Nigeria, <em>drambia44@gmail.com</em></p><p><strong>Received file:<a href="http://ujpr.org/2018/3-5-r9.pdf" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/drkk/blue_23983.gif" /></a>        Reviewer's Comments:<a href="http://ujpr.org/2018/3-5-r9-comments.docx" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/drkk/download_logo_r_29189.gif" /></a></strong></p><p><strong>Average Peer review marks at initial stage:</strong> 4.5/10</p><p><strong>Average Peer review marks at publication stage:</strong> 7.0/10</p><p><strong>Reviewer(s) detail:</strong></p><p><strong>Prof. Dr. Hüsniye Kayalar<sub><a href="https://orcid.org/0000-0001-7882-0517" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/editor/orcid22.jpg" /></a></sub></strong>, Ege University, Turkey, <em>husniyekayalar@gmail.com</em></p><p><strong>Noha El Baghdady<a href="https://orcid.org/0000-0002-0734-3036" target="_blank" rel="noopener"><img src="https://www.ujpr.org/public/site/images/editor/orcid22.jpg" /></a></strong>, MTI University, Cairo, Egypt, <em>nohasalah21@yahoo.com</em></p><p><strong>Similar Articles:</strong></p><p><a href="http://ujpr.org/index.php/journal/article/view/175">EVALUATION OF ANTIBACTERIAL RESISTANCE OF BIOFILM FORMS OF AVIAN SALMONELLA GALLINARUM TO FLUOROQUINOLONES</a></p> ER -