BIODEGRADATION OF PARACETAMOL BY NATIVE FUNGAL SPECIES INHABITING WASTEWATER OF A PHARMACEUTICAL FACTORY IN SANA’A, YEMEN

  • Wadhah Hassan Edrees Microbiology Division, Biology Department, Faculty of Science, Sana’a University
  • Qais Yusuf Abdullah Microbiology Division, Biology Department, Faculty of Science, Sana’a University
  • Khalid Mohamed Naji Chemistry Department, Faculty of Science, Sana’a University, Yemen
  • Ali Gamal AL-Kaf Medicinal Chemistry Department, Faculty of Pharmacy, Sana’a University.

Abstract

Objectives: Paracetamol has emerged as an important environmental contaminant due to its extensive use. The purpose of this work was toisolate, identify, and characterize fungal species able to degrade paracetamol from pharmaceutical wastewater effluent at Sana'a City, Yemen.


Methods: The fungi were isolated and purified from wastewater samples using enrichment and selective media. The isolated fungi were identified according to phenotypic characterization. Two species of isolated fungi were able to utilize the paracetamol as the sole of carbon and energy sources. These fungi were designated as F1 and F2 and identified as Aspergillus niger and Fusarium oxysporium, respectively. Optimum temperature and pH for growth of both species were 25˚C and 6.0, respectively. Also, the biodegradation of paracetamol was influenced by glucose concentration.


Results:  F1 and F2 were able to degrade 35.7% and 26.1% of 1000 and 2000 mg/l, respectively, paracetamol in 60 days. This is the first report on the ability of Aspergillus niger and Fusarium oxysporium to degrade paracetamol.


Conclusion:  The reported findings highlight the potential use of the isolated microorganisms for treatment of paracetamol-contaminated wastewater.


710.JPG


google_s_2.JPG


Peer Review History:


Received 8 December 2018;   Revised 11 January; Accepted 12 January, Available online 15 January 2018


UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.


Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 5.5/10


Average Peer review marks at publication stage: 7.5/10


Reviewer(s) detail:


Dr. Fátima Morales Marínorcid22.jpg, University of Murcia, Spain, fatima.morales@um.es


Dr. Naglaa Mohamed Ahmed Abd Elaalorcid22.jpg, Helwan University, Egypt, nogamoon2005@yahoo.com


Similar Articles:


A REVIEW ON COMPARATIVE STUDY BETWEEN THE PHYSICOCHEMICAL AND BIOLOGICAL PROCESSES FOR PARACETAMOL DEGRADATION

Keywords: Lozenges, HPMC K4M, Carbamazepine (CBZ), swallowing, in vitro dissolution, stability studies

Downloads

Download data is not yet available.
Comments

Statistics
278 Views | 462 Downloads
How to Cite
Edrees, W., Q. Abdullah, K. Naji, and A. AL-Kaf. “BIODEGRADATION OF PARACETAMOL BY NATIVE FUNGAL SPECIES INHABITING WASTEWATER OF A PHARMACEUTICAL FACTORY IN SANA’A, YEMEN”. Universal Journal of Pharmaceutical Research, Vol. 2, no. 6, Nov. 2017, doi:https://doi.org/10.22270/ujpr.v2i6.R7.
Section
Research Articles