ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION

  • Felix Sunday Yusuf Department of Biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria.
  • Yunus A A Department of Biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria.
  • Dingwoke Francis John Department of Biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria.
  • Udokwu Japheth Chigbo Department of Biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria.

Abstract

Objectives: Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI), antiretroviral drug; it is used in treatment of AIDS. The present study deals with the formulation and evaluation of Abacavir nanoparticles.


Methods: Abacavir nanoparticles were formulated by solvent displacement method using Eudragit RL-100, chitosan and Poloxamer-188. Nanoparticles were characterized by determining its particle size, drug entrapment efficiency, particle morphological character and in-vitro drug release.


Results:  Particle size range of nanoparticles was in the range of 121.4-140.6 nm. Zeta potential of formulations was determined, and it was found in range of 16.5-20.45 mv. The in-vitro release of nanoparticles were carried out which exhibited a sustained release of Abacavir from nanoparticles up to 10 hrs.


Conclusion:  The study concludes that nanoparticles can be a promising drug delivery system for sustained release of Abacavir in terms of increased bioavailability.


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Peer Review History:


Article received on- 15 November     Revised on- 10 December   Accepted on- 15 December, Available online 15 January 2017


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Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif


Average Peer review marks at initial stage: 4.0/10


Average Peer review marks at publication stage: 7.0/10


Reviewer(s) detail:


Dr. Kingsley C Anukamorcid22.jpg, University of Benin, Nigeria, kanukam@gmail.com


Dr. Iman Muhammad Higazyorcid22.jpg, National Research Center, Egypt, imane.higazy@hotmail.com


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Keywords: Abacavir, nanoparticles, solvent displacement method, zeta potential, entrapment efficiency

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How to Cite
Yusuf, F., Y. A, D. John, and U. Chigbo. “ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION”. Universal Journal of Pharmaceutical Research, Vol. 1, no. 2, Nov. 2016, doi:https://doi.org/10.22270/ujpr.v1i2.R2.
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Research Articles