_1568963566
1568963566
Editor
editor.jddt@gmail.com
UJPR
Universal Journal of Pharmaceutical Research
Univ J Pharm Res
2456-8058
04
11
2018
FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS
Igwe J.
Chibueze
Emenike
IV
Oduola A
R
The aim of the present investigation was to develop oral controlled release matrix tablet formulations of Finasteride with different polymer ratios. Finasteride is chemically considered a synthetic 4-azasteroid drug. The granules were evaluated for angle of repose, bulk density and Compressibility index before being punched as tablets. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and/or standard references. Different models for kinetic study were applied like zero order, first order, Higuchi, Hixson Crowell and Korsmeyer to study the release pattern and mechanism.
Google Scholar
11
01
2016
10.22270/ujpr.v1i2.R3
http://ujpr.org/index.php/journal/article/view/24
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http://ujpr.org/index.php/journal/article/download/24/16
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http://ujpr.org/index.php/journal/article/download/24/208
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http://ujpr.org/index.php/journal/article/download/24/16
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http://ujpr.org/index.php/journal/article/download/24/208