FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ANTIEPILEPTIC DRUG

  • Md. Semimul Akhtar Shri Ram Murti Smarak College of Engineering and Technology (Pharmacy), Bareilly, Uttar Pradesh, India.
10.22270/ujpr.v4i6.331

Keywords:

Bioavailability, epilepsy, fast dissolving tablet, lacosamide, pre-compression parameters

Abstract

Objective:  The objective of the present study was to prepare and evaluate the mouth dissolving tablet of lacosamide using super disintegrants like Guar Gum, and other excipients like microcrystalline cellulose and mannitol in different concentrations by direct compression method. Lacosamide has been shown to be an effective antiepileptic agent appropriate for epilepsy patients.

Methods: The mouth dissolving tablets were prepared by a single punch machine using a powder blend of super disintegrants and lacosamide. Post-compression parameters like hardness, weight variation, friability, in-vitro dispersion, drug content uniformity, and in-vitro drug release studies were carried out for all formulations.

Results: All formulations results were within official limits. Fast disintegration time obtained between 35sec. and 128 sec, was within the official limit. Different drug release kinetic models were applied for selecting batches for stability studies. These showed that there was no significant change in residual drug content in mouth dissolving tablets.

Conclusion: By the in-vitro disintegration, it is concluded that formulation prepared by Guar Gum (10%) showed faster disintegration time than that of MCC. This indicates that the use of super disintegrants increases the release of drug from the formulation. Therefore, it can be concluded that such mouth dissolving tablets are suitable delivery systems for lacosamide.

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Peer Review History:

Received 2 October  2019;   Revised 4 November; Accepted 29 December; Available online 15 January 2020

Academic Editor: Dr. Ali Abdullah Al-yahawiorcid22.jpg, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com

Received file:blue_23983.gif                Reviewer's Comments:download_logo_r_29189.gif

Average Peer review marks at initial stage: 3.0/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Dr. Iman Muhammad Higazyorcid22.jpg, National Research Center, Egypt, imane.higazy@hotmail.com

Dr. Mohamed Salamaorcid22.jpg, Modern University for Technology & Information, Egypt, salama47@yahoo.com

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Published

2020-01-15

How to Cite

Akhtar, M. S. “FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ANTIEPILEPTIC DRUG”. Universal Journal of Pharmaceutical Research, vol. 4, no. 6, Jan. 2020, doi:10.22270/ujpr.v4i6.331.

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Research Articles